The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-
surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains …

Ion channels of the Transient Receptor Potential (TRP) family mediate the influx of
monovalent and/or divalent cations into cells in response to a host of chemical or physical …

Interferons (IFNs) are pleiotropic cytokines originally identified for their antiviral activity. IFN-
α and IFN-β are both type I IFNs that have been used to treat neurological diseases such as …

Background Lung nociceptor neurons amplify immune cell activity and mucus metaplasia in
response to an inhaled allergen challenge in sensitized mice. Objective We sought to …

Joint pain is one of the most debilitating symptoms of rheumatoid arthritis (RA) and patients
frequently rate improvements in pain management as their priority. RA is hallmarked by the …

Rheumatoid arthritis–associated joint pain is frequently observed independent of disease
activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding …

Chronic pain is an unpleasant and debilitating condition that is often poorly managed by
existing therapeutics. Reciprocal interactions between the nervous system and the immune …

In this Perspectives article, we outline a proposed model for understanding the specificity
and function of anti-citrullinated protein antibodies (ACPAs). We suggest that ACPAs vary in …

Itch is a common symptom of diseases of the skin but can also accompany diseases of other
tissues including the nervous system. Acute itch from chemicals experimentally applied to …