Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a
wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are …

Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of
human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein …

Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises
from the interaction of multiple factors including tobacco, alcohol consumption, and betel …

Background & Aims Long non-coding RNAs (lncRNAs) are expressed in tissue-specific
pattern, but it is not clear how these are regulated. We aimed to identify squamous cell …

Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the
entire chromosome complement. However, despite its prevalence and prognostic relevance …

Background Patients with esophageal cancer are confronted with high mortality rates.
Whether it is esophageal squamous cell carcinoma (ESCC) or esophageal adenocarcinoma …

Esophageal squamous cell carcinoma (ESCC) is a common malignancy without effective
therapy. The exomes of more than 600 ESCCs have been sequenced in the past 4 years …

The human transcriptome contains thousands of small open reading frames (sORFs) that
encode microproteins whose functions remain largely unexplored. Here, we show that …

Human papillomavirus (HPV) is a necessary but insufficient cause of a subset of oral
squamous cell carcinomas (OSCCs) that is increasing markedly in frequency. To identify …