The host innate immunity offers the first line of defense against infection. However, recent
evidence shows that the host innate immunity is also critical in sensing the presence of …

Abstract Coenzyme Q 10 (CoQ 10), a benzoquinone present in most organisms, plays an
important role in the electron-transport chain, and its deficiency is associated with various …

Abstract PomBase (www. pombase. org), the model organism database for the fission yeast
Schizosaccharomyces pombe, has undergone a complete redevelopment, resulting in a …

Abstract N 6-methyladenosine (m6A) is a modification that plays pivotal roles in RNA
metabolism and function, although its functions in spliceosomal U6 snRNA remain unknown …

Approximately 18% of ovarian cancers have an underlying genetic predisposition and many
of the genetic alterations have become intervention and therapy targets. Although mutations …

The fission yeast Schizosaccharomyces pombe has become well established as a model
species for studying conserved cell-level biological processes, especially the mechanics …

Combination therapy can greatly improve the efficacy of cancer treatment, so identifying the
most effective drug combination and interaction can accelerate the development of …

Approaches to increase the efficiency in developing drugs and diagnostics tools, including
new drug delivery and diagnostic technologies, are needed for improved diagnosis and …

Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of
various malignancies and have garnered attention as a viable target for therapeutic …

The recent advances in pharmacogenomics have made personalized medicine no longer a
pipedream but a precise and powerful way to tailor individualized cancer treatment …