Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Macrophage polarization and meta-inflammation

C Li, MM Xu, K Wang, AJ Adler, AT Vella, B Zhou - Translational Research, 2018 - Elsevier
Chronic overnutrition and obesity induces low-grade inflammation throughout the body.
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …

Inflammation of brown/beige adipose tissues in obesity and metabolic disease

F Villarroya, R Cereijo… - Journal of internal …, 2018 - Wiley Online Library
Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases,
are related to the low‐grade chronic inflammation of white adipose tissue. Under white …

Adipose tissue macrophage in obesity-associated metabolic diseases

J Yao, D Wu, Y Qiu - Frontiers in immunology, 2022 - frontiersin.org
Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …

Brown and beige adipose tissue and aging

E Zoico, S Rubele, A De Caro, N Nori… - Frontiers in …, 2019 - frontiersin.org
Across aging, adipose tissue (AT) changes its quantity and distribution: AT becomes
dysfunctional with an increase in production of inflammatory peptides, a decline of those …

Toward an understanding of how immune cells control brown and beige adipobiology

F Villarroya, R Cereijo, J Villarroya, A Gavaldà-Navarro… - Cell metabolism, 2018 - cell.com
Immune cells were recently found to have an unexpected involvement in controlling the
thermogenic activity of brown and beige adipose tissue. Here, we review how macrophages …

[HTML][HTML] Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity

SA Nance, L Muir, C Lumeng - Molecular Metabolism, 2022 - Elsevier
Abstract Background Adipose tissue macrophages (ATMs) are a well characterized
regulator of adipose tissue inflammatory tone. Previously defined by the M1 vs M2 …

Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts

MH Grace, D Esposito, MA Timmers, J Xiong, G Yousef… - Food chemistry, 2016 - Elsevier
Phytochemical and bioactivity analyses of pistachio hulls revealed the presence of
anacardic acids (3198 mg/100 g), fatty acids (1500 mg/100 g), and phytosterols (192 mg/100 …