Signaling pathways in obesity: mechanisms and therapeutic interventions
X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …
excessive fat accumulation in the body, obesity sharply increases the risk of several …
[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …
several types of adipose tissue have been identified, namely white, brown, and beige, that …
Brown adipose tissue—a translational perspective
AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …
Macrophage polarization and meta-inflammation
Chronic overnutrition and obesity induces low-grade inflammation throughout the body.
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …
Termed “meta-inflammation,” this chronic state of inflammation is mediated by macrophages …
Inflammation of brown/beige adipose tissues in obesity and metabolic disease
F Villarroya, R Cereijo… - Journal of internal …, 2018 - Wiley Online Library
Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases,
are related to the low‐grade chronic inflammation of white adipose tissue. Under white …
are related to the low‐grade chronic inflammation of white adipose tissue. Under white …
Adipose tissue macrophage in obesity-associated metabolic diseases
Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …
Brown and beige adipose tissue and aging
E Zoico, S Rubele, A De Caro, N Nori… - Frontiers in …, 2019 - frontiersin.org
Across aging, adipose tissue (AT) changes its quantity and distribution: AT becomes
dysfunctional with an increase in production of inflammatory peptides, a decline of those …
dysfunctional with an increase in production of inflammatory peptides, a decline of those …
Toward an understanding of how immune cells control brown and beige adipobiology
Immune cells were recently found to have an unexpected involvement in controlling the
thermogenic activity of brown and beige adipose tissue. Here, we review how macrophages …
thermogenic activity of brown and beige adipose tissue. Here, we review how macrophages …
[HTML][HTML] Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity
Abstract Background Adipose tissue macrophages (ATMs) are a well characterized
regulator of adipose tissue inflammatory tone. Previously defined by the M1 vs M2 …
regulator of adipose tissue inflammatory tone. Previously defined by the M1 vs M2 …
Chemical composition, antioxidant and anti-inflammatory properties of pistachio hull extracts
Phytochemical and bioactivity analyses of pistachio hulls revealed the presence of
anacardic acids (3198 mg/100 g), fatty acids (1500 mg/100 g), and phytosterols (192 mg/100 …
anacardic acids (3198 mg/100 g), fatty acids (1500 mg/100 g), and phytosterols (192 mg/100 …