Infections caused by multidrug-resistant (MDR) bacteria are becoming a serious threat to
public health worldwide. With an ever-reducing pipeline of last-resort drugs further …

Elemental sulfur is the oldest known antimicrobial agent. However, conventional sulfur in the
clinic suffers from poor aqueous solubility and limited antibacterial activity, greatly hindering …

mRNA lipid nanoparticle (LNP) technology presents enormous opportunities to prevent and
treat various diseases. Here, we developed a novel series of LNPs containing ionizable …

Microbial infections caused by a variety of drug-resistant microorganisms are more common,
but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic …

Soft-matter nanoparticles are of great interest for their applications in biotechnology,
therapeutic delivery, and in vivo imaging. Underpinning this is their biocompatibility …

Although fusogenic liposomes offer a promising approach for the delivery of antibiotic
payloads across the cell envelope of Gram-negative bacteria, there is still a limited …

Hypothesis The study aimed to use molecular hybridization of a cationic lipid with a known
pharmacophore to produce a bifunctional lipid having a cationic charge to enhance fusion …

Mycobacterium tuberculosis (MTB) causes the infectious disease tuberculosis (TB),
responsible for more deaths than any other single infectious disease in history. Intracellular …

There is a great need for novel approaches to treating bacterial infections, due to the vast
dissemination of resistance among pathogenic bacteria. Staphylococcus aureus are …

Complex diseases such as cancer and microbial infections are multifactorial in nature with
numerous redundant signalling pathways involved in the disease development.[1–3] …