The maintenance of muscle homeostasis is vital for life and health. Skeletal muscle atrophy
not only seriously reduces people's quality of life and increases morbidity and mortality, but …

Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that
dramatically increases mortality and morbidity. The alteration of protein homeostasis is …

Metabolic diseases have a tremendous impact on human morbidity and mortality. Numerous
targets regulating adenosine monophosphate kinase (AMPK) have been identified for …

Background Skeletal muscle atrophy is characterized by muscle wasting with partial or
complete functional loss. Skeletal muscle atrophy severely affects the quality of life and …

Endocrine-disrupting chemical perfluorooctane sulfonate (PFOS) acute exposure stimulates
insulin secretion from pancreatic β-cells. However, chronic exposure to PFOS on pancreatic …

Long intergenic non-coding RNAs (lincRNAs) have been considered to play a key
regulatory role in various biological processes. An increasing number of studies have …

Aim There is growing evidence about the ability of cyclic adenosine monophosphate (cAMP)
signaling and nonselective phosphodiesterase (PDE) inhibitors on mitigate muscle atrophy …

Although pentoxifylline (PTX) was identified as a competitive non-selective
phosphodiesterase inhibitor, its pharmacological effect has not been clearly elucidated. The …

Muscle mass is maintained through an interplay between anabolic and catabolic pathways.
The ubiquitin-proteasome system plays an important role in the proteolysis progress during …

Context HuoxueJiangtang decoction (ZY) is a traditional Chinese medicine for the treatment
of diabetes. Objective The protective effect of ZY on renal injury in diabetic nephropathy rats …