Nearly 30 years of animal models to study amyotrophic lateral sclerosis: a historical overview and future perspectives
T Bonifacino, RA Zerbo, M Balbi, C Torazza… - International journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …
autonomous neurodegenerative disease characterized by upper and lower motor neuron …
Glial cells—The strategic targets in amyotrophic lateral sclerosis treatment
T Filipi, Z Hermanova, J Tureckova, O Vanatko… - Journal of clinical …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease, which is characterized by
the degeneration of motor neurons in the motor cortex and the spinal cord and subsequently …
the degeneration of motor neurons in the motor cortex and the spinal cord and subsequently …
SOCE-mediated NFAT1–NOX2–NLRP1 inflammasome involves in lipopolysaccharide-induced neuronal damage and Aβ generation
Z Sun, X Li, L Yang, X Dong, Y Han, Y Li, J Luo… - Molecular …, 2022 - Springer
The level of lipopolysaccharide (LPS) is higher in the blood and brains of patients with
Alzheimer's disease (AD), and this phenomenon is strongly linked to AD-related neuronal …
Alzheimer's disease (AD), and this phenomenon is strongly linked to AD-related neuronal …
Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1G93A mice
ALMR Tomiyama, LP Cartarozzi… - Frontiers in Cellular …, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that progressively
affects motoneurons, causing muscle atrophy and evolving to death. Astrocytes inhibit the …
affects motoneurons, causing muscle atrophy and evolving to death. Astrocytes inhibit the …
Tempol reverses the negative effects of morphine on arterial blood-gas chemistry and tissue oxygen saturation in freely-moving rats
SM Baby, JF Discala, R Gruber, PM Getsy… - Frontiers in …, 2021 - frontiersin.org
We have reported that pretreatment with the clinically approved superoxide dismutase
mimetic, Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine-N-oxyl), blunts the …
mimetic, Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine-N-oxyl), blunts the …
Systemic administration of tempol attenuates the cardiorespiratory depressant effects of fentanyl
S Baby, R Gruber, J Discala, V Puskovic… - Frontiers in …, 2021 - frontiersin.org
Fentanyl is a high-potency opioid receptor agonist that elicits profound analgesia and
suppression of breathing in humans and animals. To date, there is limited evidence as to …
suppression of breathing in humans and animals. To date, there is limited evidence as to …
MSC‐EXO and tempol ameliorate bronchopulmonary dysplasia in newborn rats by activating HIF‐1α
J Wang, A Zhang, F Huang, J Xu… - Pediatric …, 2023 - Wiley Online Library
Background Bronchopulmonary dysplasia (BPD) is a major complication of premature
infants and an important cause of morbidity and mortality. This study investigates the effect of …
infants and an important cause of morbidity and mortality. This study investigates the effect of …
Anti-Inflammatory Effects of Miyako Bidens pilosa in a Mouse Model of Amyotrophic Lateral Sclerosis and Lipopolysaccharide-Stimulated BV-2 Microglia
K Tsuruta, T Shidara, H Miyagishi, H Nango… - International Journal of …, 2023 - mdpi.com
Neuroinflammation is a fundamental feature in the pathogenesis of amyotrophic lateral
sclerosis (ALS) and arises from the activation of astrocytes and microglial cells. Previously …
sclerosis (ALS) and arises from the activation of astrocytes and microglial cells. Previously …
Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis
AL Wright, PA Della Gatta, S Le… - European Journal of …, 2021 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease commonly treated with
riluzole, a small molecule that may act via modulation of glutamatergic neurotransmission …
riluzole, a small molecule that may act via modulation of glutamatergic neurotransmission …
Brainstem involvement in amyotrophic lateral sclerosis: a combined structural and diffusion tensor MRI analysis
H Li, Q Zhang, Q Duan, J Jin, F Hu, J Dang… - Frontiers in …, 2021 - frontiersin.org
Introduction The brainstem is an important component in the pathology of amyotrophic
lateral sclerosis (ALS). Although neuroimaging studies have shown multiple structural …
lateral sclerosis (ALS). Although neuroimaging studies have shown multiple structural …