Obesity, an excess accumulation of white adipose tissue (WAT), has become a global
epidemic and is associated with complex diseases, such as type 2 diabetes and …

Drug tolerance is the basis for acquired resistance to epidermal growth factor receptor-
tyrosine kinase inhibitors (EGFR-TKIs) including osimertinib, through mechanisms that still …

There is substantial evidence that the growth hormone (GH)/insulin-like growth factor (IGF)
system is involved in the pathophysiology of obesity. Both GH and IGF-I have direct effects …

Hypothyroidism, a metabolic disease characterized by low thyroid hormone (TH) and high
thyroid-stimulating hormone (TSH) levels in the serum, is strongly associated with …

The growth hormone (GH)/insulin-like growth factor I (IGF-I) axis is involved in metabolic
control. Malnutrition reduces IGF-I and modifies the thermogenic capacity of brown adipose …

Diet-induced obesity in mice and humans is commonly associated with an imbalance
between energy intake and expenditure. Reportedly, creatine can enhance energy …

The sodium/iodide symporter (NIS) mediates active iodide (I−) accumulation in the thyroid,
the first step in thyroid hormone (TH) biosynthesis. Mutations in the SLC5A5 gene encoding …

Objective: Androgen deprivation therapy (ADT), a principal therapy in patients with prostate
cancer, is associated with the development of obesity, insulin resistance and …

Brown adipocytes are rich in mitochondria and linked to the body's blood fat levels and
obesity. MiR‐92a is negatively correlated with the activity of brown adipocytes. This study …

Objective We aimed to investigate the short and long-term metabolic consequences of
IGF1R systemic gene deficiency in mice. Methods UBC-CreERT2, Igf1rfl/fl mutant mice were …