Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

Animal studies indicate that the composition of gut microbiota may be involved in the
progression of insulin resistance to type 2 diabetes. Probiotics and/or prebiotics could be a …

Aims Sodium-glucose co-transporter 2 (SGLT2) inhibitors improve cardiovascular outcomes
in diverse patient populations, but their mechanism of action requires further study. The aim …

The enzyme lipoprotein lipase (LPL), originally identified as the clearing factor lipase,
hydrolyzes triglycerides present in the triglyceride-rich lipoproteins VLDL and chylomicrons …

The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

The heart has both the greatest caloric needs and the most robust oxidation of fatty acids
(FAs). Under pathological conditions such as obesity and type 2 diabetes, cardiac uptake …

Increasing studies have shown that obesity is the primary cause of cardiovascular diseases,
non-alcoholic fatty liver diseases, type 2 diabetes, and a variety of cancers. The dysfunction …

Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage.
Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein …

1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …

Triglycerides are carried in the bloodstream as the components of very low-density
lipoproteins and chylomicrons. These circulating triglycerides are primarily hydrolyzed in …