[HTML][HTML] Transcriptional control by premature termination: a forgotten mechanism
K Kamieniarz-Gdula, NJ Proudfoot - Trends in Genetics, 2019 - cell.com
The concept of early termination as an important means of transcriptional control has long
been established. Even so, its role in metazoan gene expression is underappreciated …
been established. Even so, its role in metazoan gene expression is underappreciated …
[HTML][HTML] Role of RNA Binding Proteins with prion-like domains in muscle and neuromuscular diseases
G Picchiarelli, L Dupuis - Cell stress, 2020 - ncbi.nlm.nih.gov
A number of neuromuscular and muscular diseases, including amyotrophic lateral sclerosis
(ALS), spinal muscular atrophy (SMA) and several myopathies, are associated to mutations …
(ALS), spinal muscular atrophy (SMA) and several myopathies, are associated to mutations …
The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separation
S Reber, D Jutzi, H Lindsay, A Devoy… - Nucleic acids …, 2021 - academic.oup.com
Liquid–liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving
force underlying the formation of membrane-less organelles. Such biomolecular …
force underlying the formation of membrane-less organelles. Such biomolecular …
[HTML][HTML] Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration
and an important therapeutic target. Our current understanding of TDP-43 …
and an important therapeutic target. Our current understanding of TDP-43 …
Exon‐independent recruitment of SRSF1 is mediated by U1 snRNP stem‐loop 3
AM Jobbins, S Campagne, R Weinmeister… - The EMBO …, 2022 - embopress.org
SRSF1 protein and U1 snRNPs are closely connected splicing factors. They both stimulate
exon inclusion, SRSF1 by binding to exonic splicing enhancer sequences (ESEs) and U1 …
exon inclusion, SRSF1 by binding to exonic splicing enhancer sequences (ESEs) and U1 …
[HTML][HTML] TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV
R Matkovic, M Morel, S Lanciano, P Larrous… - Nature …, 2022 - nature.com
Abstract The Human Silencing Hub (HUSH) complex constituted of TASOR, MPP8 and
Periphilin recruits the histone methyl-transferase SETDB1 to spread H3K9me3 repressive …
Periphilin recruits the histone methyl-transferase SETDB1 to spread H3K9me3 repressive …
[HTML][HTML] RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM
Background Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative
disease characterized by progressive loss of upper and lower motor neurons. While …
disease characterized by progressive loss of upper and lower motor neurons. While …
Causal ALS genes impact the MHC class II antigen presentation pathway
Mutations in RNA/DNA-binding proteins cause amyotrophic lateral sclerosis (ALS), but the
underlying disease mechanisms remain unclear. Here, we report that a set of ALS …
underlying disease mechanisms remain unclear. Here, we report that a set of ALS …
Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage
T Kawaguchi, MG Rollins, M Moinpour… - Journal of proteome …, 2019 - ACS Publications
The RNA-binding proteins TDP-43 and FUS are tied as the third leading known genetic
cause for amyotrophic lateral sclerosis (ALS), and TDP-43 proteopathies are found in nearly …
cause for amyotrophic lateral sclerosis (ALS), and TDP-43 proteopathies are found in nearly …
[HTML][HTML] The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis
Y Leader, G Lev Maor, M Sorek, R Shayevitch… - Nature …, 2021 - nature.com
In the earliest step of spliceosome assembly, the two splice sites flanking an intron are
brought into proximity by U1 snRNP and U2AF along with other proteins. The mechanism …
brought into proximity by U1 snRNP and U2AF along with other proteins. The mechanism …