[HTML][HTML] Monocarboxylate transporters in cancer

VL Payen, E Mina, VF Van Hée, PE Porporato… - Molecular …, 2020 - Elsevier
Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Glycolysis-mediated control of blood-brain barrier development and function

AB Salmina, NV Kuvacheva, AV Morgun… - The international journal …, 2015 - Elsevier
The blood-brain barrier (BBB) consists of differentiated cells integrating in one ensemble to
control transport processes between the central nervous system (CNS) and peripheral …

Distribution of monocarboxylate transporters in brain and choroid plexus epithelium

M Ueno, Y Chiba, R Murakami, Y Miyai, K Matsumoto… - Pharmaceutics, 2023 - mdpi.com
The choroid plexus (CP) plays central roles in regulating the microenvironment of the central
nervous system by secreting the majority of cerebrospinal fluid (CSF) and controlling its …

Immunoreactivity of receptor and transporters for lactate located in astrocytes and epithelial cells of choroid plexus of human brain

R Murakami, Y Chiba, N Nishi, K Matsumoto… - Neuroscience …, 2021 - Elsevier
Glucose metabolism produces lactate and hydrogen ions in an anaerobic environment.
Cerebral ischemia or hypoxia is believed to become progressively lactacidemic …

[HTML][HTML] Role of rno-miR-124-3p in regulating MCT1 expression in rat brain after permanent focal cerebral ischemia

S Xu, X Jiang, Q Liu, J Xu, J Huang, S Gan, W Lu… - Genes & …, 2019 - Elsevier
This study aimed to assess the role of microRNAs (miRNAs) in regulating monocarboxylate
transporter-1 (MCT1) expression in rat brain after permanent focal cerebral ischemia to …

Regulation of monocarboxylic acid transporter 1 trafficking by the canonical Wnt/β-catenin pathway in rat brain endothelial cells requires cross-talk with Notch …

Z Liu, M Sneve, TA Haroldson, JP Smith… - Journal of Biological …, 2016 - ASBMB
The transport of monocarboxylate fuels such as lactate, pyruvate, and ketone bodies across
brain endothelial cells is mediated by monocarboxylic acid transporter 1 (MCT1). Although …

[HTML][HTML] Identification of osteoporosis markers through bioinformatic functional analysis of serum proteome

M Lv, C Cui, P Chen, Z Li - Medicine, 2020 - journals.lww.com
Osteoporosis is a severe chronic skeletal disorder that increases the risks of disability and
mortality; however, the mechanism of this disease and the protein markers for prognosis of …

Gnal haploinsufficiency causes genomic instability and increased sensitivity to haloperidol

MM Khan, J Xiao, TJ Hollingsworth, D Patel… - Experimental …, 2019 - Elsevier
GNAL encodes guanine nucleotide-binding protein subunit Gα (olf) which plays a key role in
striatal medium spiny neuron (MSN)-dopamine signaling. GNAL loss-of-function mutations …

The rete mirabile: a possible control site for swimbladder function

B Pelster - Journal of Comparative Physiology B, 2023 - Springer
In a recent study, a large number of transport proteins was detected in the transcriptome and
proteome of saline perfused rete mirabile tissue of the European eel. In this study, the data …

The Complementary Roles of Glucose and Lactate in Meeting Neuronal Energetic Needs: An Investigation into the Modulation of Cortical Metabolism and …

A Béland - 2023 - ruor.uottawa.ca
Our knowledge of cerebral metabolism is shifting towards an understanding and
appreciation of non-neuronal and non-glucose contributions to meeting the brains high …