Marine invertebrates provide a rich source of metabolites with anticancer activities and
several marine-derived agents have been approved for the treatment of cancer. However …

Pd (II)-catalyzed E/Z isomerization of alkenes is a common process, yet its mechanism
remains largely uncharacterized, particularly with nonconjugated alkenes. In this work, the …

A crepuscular catalyst: Alkene migration catalyzed by [(RCN) 2 PdCl 2] complexes proceeds
through an in situ generated Pd‐H species. Addition of a 1, 5‐diene inhibits migration and …

Pancreatic cancer, the 4th leading cause of cancer death in the US, is highly resistant to all
current chemotherapies, and its growth is facilitated by chronic inflammation. An important …

Abstract The alkyne to 1, 3-diene isomerization reaction is a process in which a nucleophilic
phosphine catalyst promotes the rearrangement of an electron-withdrawing group activated …

The chemical synthesis of the palmerolides is the subject of this review. The palmerolides
are a family of Antarctic marine natural products, many of which display potent and selective …

The total synthesis of dehydromicrosclerodermin B and microsclerodermin J is described.
Efficient approaches to the unusual amino acids in the target molecules were developed on …

An efficient formal total synthesis of the PKC inhibitor balanol 1 is described, starting from
the commercially available pentane1, 5-diol. A Shi epoxidation and Pd (0)-mediated …

The asymmetric synthesis of the fully functionalized macrocyclic core of iriomoteolide 3a, a
cytotoxic 15-membered macrolide, is disclosed. The key steps involve Sharpless asymmetric …

Efficient asymmetric syntheses of APTO and AETD, the highly functionalized β-amino acid
fragments within microsclerodermins C, D, and E, are reported. The conjugate addition of …