Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Irritable bowel syndrome (IBS) is a functional disorder which affects a large proportion of the
population globally. The precise etiology of IBS is still unknown, although consensus …

There is a growing emphasis on the relationship between the complexity and diversity of the
microorganisms that inhabit our gut (human gastrointestinal microbiota) and health/disease …

Within the last decade, research regarding the human gut microbiome has exploded. While
the gastrointestinal tract was once regarded simply as a digestive organ, new technologies …

Early-life stress is a determinant of vulnerability to a variety of disorders that include
dysfunction of the brain and gut. Here we exploit a model of early-life stress, maternal …

Visceral pain is a global term used to describe pain originating from the internal organs of
the body, which affects a significant proportion of the population and is a common feature of …

There are many known risk factors for chronic pain conditions, yet the biological
underpinnings that link these factors to abnormal processing of painful signals are only just …

The realization that the microbiota–gut–brain axis plays a critical role in health and disease
has emerged over the past decade. The brain–gut axis is a bidirectional communication …

The gut–brain axis is the bidirectional communication between the gut and the brain, which
occurs through multiple pathways that include hormonal, neural and immune mediators. The …

The prenatal and postnatal early-life periods are both dynamic and vulnerable windows for
brain development. During these important neurodevelopmental phases, essential …