Neisseria meningitidis (the meningococcus) causes significant morbidity and mortality in
children and young adults worldwide through epidemic or sporadic meningitis and/or …

Meningococcus, an obligate human bacterial pathogen, remains a worldwide and
devastating cause of epidemic meningitis and sepsis. However, advances have been made …

The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

During periods of endemic disease, about 10% of the general population harbour Neisseria
meningitidis in the nasopharynx. Since N. meningitidis is a strict human pathogen and most …

Until the introduction of antibiotics in the 1930s and 1940s, acute bacterial meningitis was
fatal in most cases. Since then it has become curable with a variable mortality and morbidity …

No bacterial disease has undergone a more dramatic change in epidemiology during the
past decade than acute bacterial meningitis. This review describes the changing …

Many bacterial pathogens express lipooligosaccharides that mimic human cell surface
glycoconjugates, enabling them to attach to host receptors and to evade the immune …

Meningococcal disease remains an important cause of morbidity and death worldwide
despite the development and increasing implementation of effective vaccines. Elimination of …

The distribution of serogroups and multilocus sequence types (STs) in collections of disease-
associated and carried meningococci from the period 1991 to 2000 in three European …

Since the first outbreaks of meningococcal meningitis were first described in Geneva in 1804
and in New England in 1806, and since the discovery of the causative agent by in 1887 and …