Glycosylation in health and disease

C Reily, TJ Stewart, MB Renfrow, J Novak - Nature Reviews Nephrology, 2019 - nature.com
The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …

N-glycosylation and inflammation; the not-so-sweet relation

B Radovani, I Gudelj - Frontiers in immunology, 2022 - frontiersin.org
Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …

A novel protein glycan biomarker and future cardiovascular disease events

AO Akinkuolie, JE Buring, PM Ridker… - Journal of the American …, 2014 - Am Heart Assoc
Background Glycosylated proteins partake in multiple cellular processes including
inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N‐acetyl …

[HTML][HTML] Glycosylation in the tumor microenvironment: implications for tumor angiogenesis and metastasis

KB Chandler, CE Costello, N Rahimi - Cells, 2019 - ncbi.nlm.nih.gov
Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development,
emerging evidence indicates that tumor microenvironment-mediated changes in …

[HTML][HTML] Monocyte adhesion to the endothelium is an initial stage of atherosclerosis development

S Čejková, I Králová-Lesná, R Poledne - Cor et Vasa, 2016 - Elsevier
The formation of atherosclerotic plaque is a long and very complex process. The first signs of
development of atherosclerosis occur in areas where the blood vessels are strongly …

The importance of the vascular endothelial barrier in the immune-inflammatory response induced by radiotherapy

O Guipaud, C Jaillet, K Clément-Colmou… - The British journal of …, 2018 - academic.oup.com
Altered by ionising radiation, the vascular network is considered as a prime target to limit
normal tissue damage and improve tumour control in radiotherapy (RT). Irradiation damages …

Pioglitazone slows progression of atherosclerosis in prediabetes independent of changes in cardiovascular risk factors

A Saremi, DC Schwenke, TA Buchanan… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—To determine whether changes in standard and novel risk factors during the
Actos Now for Prevention of Diabetes trial explained the slower rate of carotid intima media …

Emerging roles of protein mannosylation in inflammation and infection

I Loke, D Kolarich, NH Packer… - Molecular aspects of …, 2016 - Elsevier
Proteins are frequently modified by complex carbohydrates (glycans) that play central roles
in maintaining the structural and functional integrity of cells and tissues in humans and lower …

Endothelial heterogeneity and adhesion molecules N-glycosylation: implications in leukocyte trafficking in inflammation

DW Scott, RP Patel - Glycobiology, 2013 - academic.oup.com
Inflammation is a major contributing element to a host of diseases with the interaction
between leukocytes and the endothelium being key in this process. Much is understood …

Reduced mannosidase MAN1A1 expression leads to aberrant N-glycosylation and impaired survival in breast cancer

K Legler, R Rosprim, T Karius, K Eylmann… - British journal of …, 2018 - nature.com
Background: Alterations in protein glycosylation have been related to malignant
transformation and tumour progression. We recently showed that low mRNA levels of Golgi …