Glycosylation in health and disease
C Reily, TJ Stewart, MB Renfrow, J Novak - Nature Reviews Nephrology, 2019 - nature.com
The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …
N-glycosylation and inflammation; the not-so-sweet relation
B Radovani, I Gudelj - Frontiers in immunology, 2022 - frontiersin.org
Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …
A novel protein glycan biomarker and future cardiovascular disease events
AO Akinkuolie, JE Buring, PM Ridker… - Journal of the American …, 2014 - Am Heart Assoc
Background Glycosylated proteins partake in multiple cellular processes including
inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N‐acetyl …
inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N‐acetyl …
[HTML][HTML] Glycosylation in the tumor microenvironment: implications for tumor angiogenesis and metastasis
Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development,
emerging evidence indicates that tumor microenvironment-mediated changes in …
emerging evidence indicates that tumor microenvironment-mediated changes in …
[HTML][HTML] Monocyte adhesion to the endothelium is an initial stage of atherosclerosis development
S Čejková, I Králová-Lesná, R Poledne - Cor et Vasa, 2016 - Elsevier
The formation of atherosclerotic plaque is a long and very complex process. The first signs of
development of atherosclerosis occur in areas where the blood vessels are strongly …
development of atherosclerosis occur in areas where the blood vessels are strongly …
The importance of the vascular endothelial barrier in the immune-inflammatory response induced by radiotherapy
O Guipaud, C Jaillet, K Clément-Colmou… - The British journal of …, 2018 - academic.oup.com
Altered by ionising radiation, the vascular network is considered as a prime target to limit
normal tissue damage and improve tumour control in radiotherapy (RT). Irradiation damages …
normal tissue damage and improve tumour control in radiotherapy (RT). Irradiation damages …
Pioglitazone slows progression of atherosclerosis in prediabetes independent of changes in cardiovascular risk factors
Objective—To determine whether changes in standard and novel risk factors during the
Actos Now for Prevention of Diabetes trial explained the slower rate of carotid intima media …
Actos Now for Prevention of Diabetes trial explained the slower rate of carotid intima media …
Emerging roles of protein mannosylation in inflammation and infection
Proteins are frequently modified by complex carbohydrates (glycans) that play central roles
in maintaining the structural and functional integrity of cells and tissues in humans and lower …
in maintaining the structural and functional integrity of cells and tissues in humans and lower …
Endothelial heterogeneity and adhesion molecules N-glycosylation: implications in leukocyte trafficking in inflammation
DW Scott, RP Patel - Glycobiology, 2013 - academic.oup.com
Inflammation is a major contributing element to a host of diseases with the interaction
between leukocytes and the endothelium being key in this process. Much is understood …
between leukocytes and the endothelium being key in this process. Much is understood …
Reduced mannosidase MAN1A1 expression leads to aberrant N-glycosylation and impaired survival in breast cancer
K Legler, R Rosprim, T Karius, K Eylmann… - British journal of …, 2018 - nature.com
Background: Alterations in protein glycosylation have been related to malignant
transformation and tumour progression. We recently showed that low mRNA levels of Golgi …
transformation and tumour progression. We recently showed that low mRNA levels of Golgi …