The critical step in the development of novel approaches to prevent disease is the
translation of laboratory concepts to clinically useful interventions. The expanding database …

Despite the beneficial effects of estrogens in women's health, there is a plethora of evidence
that suggest an important role for these hormones, particularly 17β-estradiol (E2), in the …

4-Hydroxylation is an important pathway of tamoxifen metabolism because the product of
this reaction is intrinsically 100 times more potent as an oestrogen receptor antagonist than …

The metabolism of tamoxifen is being redefined in the light of several important
pharmacological observations. Recent studies have identified 4-hydroxy N …

5,401,730 3/1995 Sauvage et al...... 514/165 having, or at risk of, an indication associated
with a TGF 5,411,988 5/1995 Bockow et al...... 514/560 beta deficiency comprising …

2019-05-26 Assigned to CAPITAL ONE, NATIONAL ASSOCIATION, AS ADMINISTRATIVE
AGENT reassignment CAPITAL ONE, NATIONAL ASSOCIATION, AS ADMINISTRATIVE …

Tamoxifen is an anti-oestrogenic drug widely used for adjuvant therapy of breast cancer. Its
use has caused an increased incidence of endometrial cancer and it is also a potent …

OCPULSALLJBRFO-UHFFFAOYSA-L CC1= C (C) C (C)= C2C (= C1C) C1= C (C3= C (C4=
C (C (C)= C (C) C (C)= C4C) N3C) C3= C1C (C) N (C) C3C) N2C. CC1= C (C) C (C)= C2C …

Quinone methides (QMs) are electrophiles formed in several biological processes including
direct oxidations of 4-alkylphenols by cytochromes P450. These species may be responsible …

The anti-oestrogen tamoxifen, which is widely used as adjuvant therapy for breast cancer, is
undergoing evaluation as a chemopreventive agent in women at increased risk of …