Resistance-proof antimicrobial drug discovery to combat global antimicrobial resistance threat

A Upadhayay, J Ling, D Pal, Y Xie, FF Ping… - Drug Resistance …, 2023 - Elsevier
Drug resistance is well-defined as a serious problem in our living world. To survive,
microbes develop defense strategies against antimicrobial drugs. Drugs exhibit less or no …

In vitro techniques and measurements of phage characteristics that are important for phage therapy success

T Glonti, JP Pirnay - Viruses, 2022 - mdpi.com
Validated methods for phage selection, host range expansion, and lytic activity
determination are indispensable for maximizing phage therapy outcomes. In this review, we …

Processing phage therapy requests in a Brussels military hospital: lessons identified

S Djebara, C Maussen, D De Vos, M Merabishvili… - Viruses, 2019 - mdpi.com
There is a growing interest in phage therapy as a complementary tool against antimicrobial
resistant infections. Since 2007, phages have been used sporadically to treat bacterial …

Bacteriophage therapy for the prevention and treatment of fracture-related infection caused by Staphylococcus aureus: a preclinical study

J Onsea, V Post, T Buchholz, H Schwegler… - Microbiology …, 2021 - Am Soc Microbiol
Although several studies have shown promising clinical outcomes of phage therapy in
patients with orthopedic device-related infections, questions remain regarding the optimal …

In Vitro Evaluation of a Phage Cocktail Controlling Infections with Escherichia coli

IHE Korf, S Kittler, A Bierbrodt, R Mengden, C Rohde… - Viruses, 2020 - mdpi.com
Worldwide, poultry industry suffers from infections caused by avian pathogenic Escherichia
coli. Therapeutic failure due to resistant bacteria is of increasing concern and poses a threat …

A phage therapy guide for clinicians and basic scientists: background and highlighting applications for developing countries

A Khalid, RCY Lin, JR Iredell - Frontiers in Microbiology, 2021 - frontiersin.org
Approximately 10% of global health research is devoted to 90% of global disease burden
(the so-called “10/90 Gap”) and it often neglects those diseases most prevalent in low …

Characteristics of a Series of Three Bacteriophages Infecting Salmonella enterica Strains

K Kosznik-Kwaśnicka, K Ciemińska, M Grabski… - International journal of …, 2020 - mdpi.com
Molecular and functional characterization of a series of three bacteriophages, vB_SenM-1,
vB_SenM-2, and vB_SenS-3, infecting various Salmonella enterica serovars and strains is …

Why is eradicating typhoid fever so challenging: implications for vaccine and therapeutic design

YA Yang, A Chong, J Song - Vaccines, 2018 - mdpi.com
Salmonella enterica serovar Typhi (S. Typhi) and S. Paratyphi, namely typhoidal
Salmonellae, are the cause of (para) typhoid fever, which is a devastating systemic …

Integrative omics analysis of Pseudomonas aeruginosa virus PA5oct highlights the molecular complexity of jumbo phages

C Lood, K Danis‐Wlodarczyk… - Environmental …, 2020 - Wiley Online Library
Summary Pseudomonas virus vB_PaeM_PA5oct is proposed as a model jumbo
bacteriophage to investigate phage‐bacteria interactions and is a candidate for phage …

Clinical Pharmacology of Bacteriophage Therapy: A Focus on Multidrug-Resistant Pseudomonas aeruginosa Infections

D Holger, R Kebriaei, T Morrisette, K Lev, J Alexander… - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa is one of the most common causes of healthcare-associated
diseases and is among the top three priority pathogens listed by the World Health …