Understanding protein function often necessitates characterizing the flexibility of protein
structures. However, simulating protein flexibility poses significant challenges due to the …

Abstract Aggrescan4D (A4D) is an advanced computational tool designed for predicting
protein aggregation, leveraging structural information and the influence of pH. Building upon …

Protein aggregation is behind the genesis of incurable diseases and imposes constraints on
drug discovery and the industrial production and formulation of proteins. Over the years, we …

Amyloidosis is a condition marked by misfolded proteins that build up in tissues and
eventually destroy organs. It has been connected to a number of fatal illnesses, including …

In the field of protein engineering, the function and structure of proteins are key to
understanding cellular mechanisms, biological evolution, and biodiversity. With the …

The recent coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has spurred intense research efforts to …

Protein aggregation is responsible for several degenerative conditions in humans, and it is
also a bottleneck in industrial protein production and storage of biotherapeutics …

Although implicated as deleterious in many organisms, aneuploidy can underlie rapid
phenotypic evolution. However, aneuploidy will only be maintained if the benefit outweighs …