As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …

Family C G-protein-coupled receptors (GPCRs) operate as obligate dimers with extracellular
domains that recognize small ligands, leading to G-protein activation on the transmembrane …

INTRODUCTION Transmembrane signaling of heterotrimeric guanine nucleotide–binding
protein (G protein)–coupled receptors (GPCRs) is mediated by ligand-dependent …

The metabotropic glutamate receptors (mGlus) have key roles in modulating cell excitability
and synaptic transmission in response to glutamate (the main excitatory neurotransmitter in …

The D2 dopamine receptor (DRD2) is a therapeutic target for Parkinson's disease and
antipsychotic drugs. DRD2 is activated by the endogenous neurotransmitter dopamine and …

G-protein-coupled receptors do not only feature the orthosteric pockets, where most
endogenous agonists bind, but also a multitude of other allosteric pockets that have come …

The metabotropic glutamate receptors (mGlus) are involved in the modulation of synaptic
transmission and neuronal excitability in the central nervous system. These receptors …

Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …

Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions
responsible for memory and learning. It plays a key role in modulating rapid changes in …