Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies

M Broekgaarden, R Weijer, TM van Gulik… - Cancer and Metastasis …, 2015 - Springer
Photodynamic therapy (PDT) has emerged as a promising alternative to conventional
cancer therapies such as surgery, chemotherapy, and radiotherapy. PDT comprises the …

GADD45 proteins: central players in tumorigenesis

RE Tamura, JF de Vasconcellos… - Current molecular …, 2012 - ingentaconnect.com
The Growth Arrest and DNA Damage-inducible 45 (GADD45) proteins have been implicated
in regulation of many cellular functions including DNA repair, cell cycle control, senescence …

The UV response of the skin: a review of the MAPK, NFκB and TNFα signal transduction pathways

V Muthusamy, TJ Piva - Archives of dermatological research, 2010 - Springer
The sun emits different types of ultraviolet (UV) light. Our skin is a natural target of UV
radiation which is involved in vitamin D 3 production in our body. UV radiation at high doses …

[HTML][HTML] Gadd45 in stress signaling

DA Liebermann, B Hoffman - Journal of molecular signaling, 2008 - Springer
Gadd45 genes have been implicated in stress signaling in response to physiological or
environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and …

Checkpoint control and cancer

RH Medema, L Macůrek - Oncogene, 2012 - nature.com
DNA-damaging therapies represent the most frequently used non-surgical anticancer
strategies in the treatment of human tumors. These therapies can kill tumor cells, but at the …

Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis

N Hanagata, F Zhuang, S Connolly, J Li, N Ogawa… - ACS …, 2011 - ACS Publications
This study proposes a molecular mechanism for lung epithelial A549 cell response to
copper oxide nanoparticles (CuO-NPs) related to Cu ions released from CuO-NPs. Cells that …

Gadd45 stress sensors in malignancy and leukemia

D Liebermann, JS Tront, X Sha… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Gadd45 proteins, including Gadd45a, Gadd45b, and Gadd45g, have been implicated in
stress signaling in response to physiological and environmental stress, including oncogenic …

GADD45G functions in male sex determination by promoting p38 signaling and Sry expression

MS Gierl, WH Gruhn, A von Seggern, N Maltry… - Developmental cell, 2012 - cell.com
Male sex determination in mammals is induced by Sry, a gene whose regulation is poorly
understood. Here we show that mice mutant for the stress-response gene Gadd45g display …

[HTML][HTML] Stress sensor Gadd45 genes as therapeutic targets in cancer

A Cretu, X Sha, J Tront, B Hoffman… - Cancer therapy, 2009 - ncbi.nlm.nih.gov
Gadd45 genes have been implicated in stress signaling responses to various physiological
or environmental stressors, resulting in cell cycle arrest, DNA repair, cell survival and …

Protective interaction of human phagocytic APC subsets with Cryptococcus neoformans induces genes associated with metabolism and antigen presentation

BN Nelson, CS Daugherty, RR Sharp… - Frontiers in …, 2022 - frontiersin.org
Cryptococcal meningitis is the most common cause of meningitis among HIV/AIDS patients
in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than …