Chitosan on the surface of nanoparticles for enhanced drug delivery: A comprehensive review

MH Elkomy, AA Ali, HM Eid - Journal of Controlled Release, 2022 - Elsevier
The ability of chitosan (CTS) to promote mucoadhesion, trigger positive/negative surface
interactions, and open tight junctions has inspired researchers to coat lipid-based and …

Surface modification of lipid-based nanocarriers: a potential approach to enhance targeted drug delivery

S Priya, VM Desai, G Singhvi - ACS omega, 2022 - ACS Publications
Nanocarriers have the utmost significance for advancements in drug delivery and
nanomedicine technology. They are classified as polymer-based nanocarriers, lipid-based …

Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis

MB Zewail, SA El-Gizawy, GF Asaad… - International Journal of …, 2023 - Elsevier
Rheumatoid arthritis (RA), a distressing inflammatory autoimmune disease, is managed
mainly by Disease-modifying antirheumatic drugs (DMARDs), eg leflunomide (LEF). LEF …

Polysaccharide-based transdermal drug delivery

J Li, H Xiang, Q Zhang, X Miao - Pharmaceuticals, 2022 - mdpi.com
Materials derived from natural plants and animals have great potential for transdermal drug
delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources …

Oral delivery of psoralidin by mucoadhesive surface-modified bilosomes showed boosted apoptotic and necrotic effects against breast and lung cancer cells

RA Youness, AM Al-Mahallawi, FH Mahmoud, H Atta… - Polymers, 2023 - mdpi.com
This study aims to design and optimize chitosan-coated bilosomal formulations loaded with
psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and …

Tailoring of novel bile salt stabilized vesicles for enhanced transdermal delivery of simvastatin: a new therapeutic approach against inflammation

ES Khafagy, BK Almutairy, AS Abu Lila - Polymers, 2023 - mdpi.com
Simvastatin (SMV), a cholesterol-lowering agent, has antioxidant and anti-inflammatory
effects. Nevertheless, the oral use of SMV is linked with poor systemic bioavailability owing …

Formulation of miconazole-loaded chitosan–carbopol vesicular gel: optimization to in vitro characterization, irritation, and antifungal assessment

SS Imam, SJ Gilani, A Zafar, MNB Jumah, S Alshehri - Pharmaceutics, 2023 - mdpi.com
Miconazole nitrate (MN) is a poorly water-soluble and antifungal drug used for fungal
infections. The present research work was designed to develop topical MN-loaded …

Intranasal delivery of granisetron to the brain via nanostructured cubosomes-based in situ gel for improved management of chemotherapy-induced emesis

EM Eissa, MH Elkomy, HM Eid, AA Ali, MAS Abourehab… - Pharmaceutics, 2022 - mdpi.com
This research aimed to boost granisetron (GS) delivery to the brain via the intranasal route to
better manage chemotherapy-induced emesis. Glycerol monooleate (GMO), Poloxamer 407 …

Novel bile salt stabilized vesicles-mediated effective topical delivery of diclofenac sodium: A new therapeutic approach for pain and inflammation

TM Mahmoud, MM Nafady, HO Farouk, DM Mahmoud… - Pharmaceuticals, 2022 - mdpi.com
The oral delivery of diclofenac sodium (DNa), a non-steroidal analgesic, anti-inflammatory
drug, is associated with various gastrointestinal side effects. The aim of the research was to …

Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: Improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic …

MH Elkomy, HM Eid, M Elmowafy, K Shalaby… - Drug …, 2022 - Taylor & Francis
Diabetes mellitus is a life-threatening metabolic disease. At the moment, there is no effective
treatment available to combat it. In this study, we aimed to develop berberine-loaded …