The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
The molecular details of cytokine signaling via the JAK/STAT pathway
More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …
induce inflammation and control the immune response. Cytokines are secreted …
A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
E Platanitis, D Demiroz, A Schneller, K Fischer… - Nature …, 2019 - nature.com
Cells maintain the balance between homeostasis and inflammation by adapting and
integrating the activity of intracellular signaling cascades, including the JAK-STAT pathway …
integrating the activity of intracellular signaling cascades, including the JAK-STAT pathway …
Regulatory networks involving STATs, IRFs, and NFκB in inflammation
E Platanitis, T Decker - Frontiers in immunology, 2018 - frontiersin.org
Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to
tailor these alterations in gene expression to the requirements of the inflammatory process …
tailor these alterations in gene expression to the requirements of the inflammatory process …
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency
N Hernandez, I Melki, H Jing, T Habib… - Journal of Experimental …, 2018 - rupress.org
Life-threatening pulmonary influenza can be caused by inborn errors of type I and III IFN
immunity. We report a 5-yr-old child with severe pulmonary influenza at 2 yr. She is …
immunity. We report a 5-yr-old child with severe pulmonary influenza at 2 yr. She is …
Direct inhibition of IRF-dependent transcriptional regulatory mechanisms associated with disease
A Antonczyk, B Krist, M Sajek, A Michalska… - Frontiers in …, 2019 - frontiersin.org
Interferon regulatory factors (IRFs) are a family of homologous proteins that regulate the
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …
The JAK-STAT pathway: from structural biology to cytokine engineering
Y Lv, J Qi, JJ Babon, L Cao, G Fan, J Lang… - … and Targeted Therapy, 2024 - nature.com
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
serves as a paradigm for signal transduction from the extracellular environment to the …
serves as a paradigm for signal transduction from the extracellular environment to the …
Structural basis for STAT2 suppression by flavivirus NS5
Suppressing cellular signal transducers of transcription 2 (STAT2) is a common strategy that
viruses use to establish infections, yet the detailed mechanism remains elusive, owing to a …
viruses use to establish infections, yet the detailed mechanism remains elusive, owing to a …
Type I interferon signaling, regulation and gene stimulation in chronic virus infection
S Lukhele, GM Boukhaled, DG Brooks - Seminars in immunology, 2019 - Elsevier
Abstract Type I Interferons (IFN-I) mediate numerous immune interactions during viral
infections, from the establishment of an antiviral state to invoking and regulating innate and …
infections, from the establishment of an antiviral state to invoking and regulating innate and …
IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression
J Nan, Y Wang, J Yang… - Proceedings of the …, 2018 - National Acad Sciences
In response to IFNβ, the IL6 gene is activated, modestly at early times by ISGF3 (IRF9 plus
tyrosine-phosphorylated STATs 1 and 2), and strongly at late times by U-ISGF3 (IRF9 plus U …
tyrosine-phosphorylated STATs 1 and 2), and strongly at late times by U-ISGF3 (IRF9 plus U …