Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Silent information regulator factor 2-related enzyme 1 (sirtuin 1, Sirt1) is a nicotinamide
adenine dinucleotide-dependent deacetylase, which can deacetylate histone and non …

Abstract Silent information regulator 1 (SIRT 1), a type of histone deacetylase, is a highly
effective therapeutic target for protection against ischemia reperfusion (IR) injury (IRI) …

Abstract Silent information regulator 1 (SIRT1), a histone deacetylase, has been suggested
to be effective in ischemic brain diseases. Salvianolic acid B (SalB) is a polyphenolic and …

Stroke represents one of the most common causes of brain's vulnerability for many millions
of people worldwide. The plethora of physiopathological events associated with brain …

Cadmium (Cd) is a widespread environment contaminant due to the development of
electroplating and metallurgical industry. Cd can be enriched by organisms via food chain …

Ischemic preconditioning (IPC) via protein kinase C epsilon (PKCε) activation induces
neuroprotection against lethal ischemia. Brain-derived neurotrophic factor (BDNF) is a pro …

Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a
lack of blood flow to the brain that results in cell death and damage, ultimately causing …

Abstract Sirtuin 5 (SIRT5) is a mitochondrial-localized NAD+-dependent lysine
desuccinylase and a major regulator of the mitochondrial succinylome. We wanted to …

Preserving mitochondrial pools of nicotinamide adenine dinucleotide (NAD) or nicotinamide
phosphoribosyltransferase (Nampt), an enzyme involved in NAD production, maintains …