From molecules to behavior: Implications for perineuronal net remodeling in learning and memory

B Sanchez, P Kraszewski, S Lee… - Journal of …, 2024 - Wiley Online Library
Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures found
throughout the central nervous system that regulate plasticity. They consist of a …

Perineuronal nets: subtle structures with large implications

H Carceller, Y Gramuntell, P Klimczak… - The …, 2023 - journals.sagepub.com
Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

A comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin in the adult mouse brain

L Lupori, V Totaro, S Cornuti, L Ciampi, F Carrara… - Cell Reports, 2023 - cell.com
Perineuronal nets (PNNs) surround specific neurons in the brain and are involved in various
forms of plasticity and clinical conditions. However, our understanding of the PNN role in …

[HTML][HTML] Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43Q331K ALS model mice

SW Cheung, EF Willis, DG Simmons… - Neurobiology of …, 2024 - Elsevier
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons
and their proximal dendrites. PNNs play an important role in neuroprotection against …

Fine structure analysis of perineuronal nets in the ketamine model of schizophrenia

R Kaushik, N Lipachev, G Matuszko… - European Journal of …, 2021 - Wiley Online Library
Perineuronal nets (PNNs) represent a highly condensed specialized form of brain
extracellular matrix (ECM) enwrapping mostly parvalbumin‐positive interneurons in the …

Multiple particle tracking detects changes in brain extracellular matrix and predicts neurodevelopmental age

M McKenna, D Shackelford, H Ferreira Pontes, B Ball… - ACS …, 2021 - ACS Publications
Brain extracellular matrix (ECM) structure mediates many aspects of neural development
and function. Probing structural changes in brain ECM could thus provide insights into …

Recovery of Forearm and fine digit function after chronic spinal cord Injury by Simultaneous Blockade of Inhibitory Matrix Chondroitin Sulfate Proteoglycan Production …

AJ Milton, JCF Kwok, J McClellan, SG Randall… - Journal of …, 2023 - liebertpub.com
Spinal cord injuries (SCI), for which there are limited effective treatments, result in enduring
paralysis and hypoesthesia, in part because of the inhibitory microenvironment that …

Proteoglycans and glycosaminoglycans in central nervous system injury

N Siddiqui, K Oshima… - American Journal of …, 2022 - journals.physiology.org
The brain and spinal cord constitute the central nervous system (CNS), which when injured,
can be exceedingly devastating. The mechanistic roles of proteoglycans (PGs) and their …

The tetrapartite synapse in neuropsychiatric disorders: Matrix metalloproteinases (MMPs) as promising targets for treatment and rational drug design

AJM Chaves Filho, M Mottin, DB Lós, CH Andrade… - Biochimie, 2022 - Elsevier
Inflammation and an exacerbated immune response are widely accepted contributing
mechanisms to the genesis and progression of major neuropsychiatric disorders. However …

Postnatal fluoxetine treatment alters perineuronal net formation and maintenance in the hippocampus

S Mukhopadhyay, A Chatterjee, P Tiwari, U Ghai… - ENeuro, 2021 - eneuro.org
Elevation of serotonin via postnatal fluoxetine (PNFlx) treatment during critical temporal
windows is hypothesized to perturb the development of limbic circuits thus establishing a …