Abstract Type 2 diabetes (T2D) is a disease characterized by heterogeneously progressive
loss of islet β cell insulin secretion usually occurring after the presence of insulin resistance …

Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis.
Hyperglycemia leads to many serious complications, but also directly initiates the process of …

Type 2 diabetes mellitus, which is usually a result of wrong dietary habits and reduced
physical activity, represents 85-95% of all diabetes cases and among other diet related …

FoxO1 是叉头转录家族O 亚族的一类代谢性调节因子, 通过磷酸化, 乙酰化,
泛素化修饰等方式调控多种基因的表达. FoxO1 可以结合于PDX-1 基因的启动子上 …

Objective Insulin release from pancreatic β-cells is controlled by plasma glucose levels via
mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on …

Progressive research in the past decade converges to the impact of PHLPP in regulating the
cellular metabolism through PI3K/AKT inhibition. Aberrations in PKB/AKT signaling …

Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than
radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of …

Diabetes is a major health problem worldwide. It is a chronic metabolic disorder that
produces overt hyperglycemic condition that occurs either when the pancreas does not …

FoxO1 is a metabolic regulator of the O subfamily in the forkhead transcription family, which
regulates the expression of a variety of genes through phosphorylation, acetylation, and …

Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis.
Hyperglycemia leads to many serious complications, but also directly initiates the process of …