International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
The role of descending pain modulation in chronic primary pain: potential application of drugs targeting serotonergic system
ZY Tao, PX Wang, SQ Wei, RJ Traub, JF Li… - Neural …, 2019 - Wiley Online Library
Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor
A Levit Kaplan, RT Strachan, JM Braz… - Journal of medicinal …, 2022 - ACS Publications
The 5-HT5A receptor (5-HT5AR), for which no selective agonists and a few antagonists
exist, remains the least understood serotonin receptor. A single commercial antagonist, SB …
exist, remains the least understood serotonin receptor. A single commercial antagonist, SB …
Role of descending serotonergic fibers in the development of pathophysiology after spinal cord injury (SCI): Contribution to chronic pain, spasticity, and autonomic …
GNK Fauss, KE Hudson, JW Grau - Biology, 2022 - mdpi.com
Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …
5-HT1F Receptor Agonist Ameliorates Mechanical Allodynia in Neuropathic Pain via Induction of Mitochondrial Biogenesis and Suppression of Neuroinflammation
LQ Zhang, YQ Zhou, JY Li, J Sun, S Zhang… - Frontiers in …, 2022 - frontiersin.org
Neuropathic pain is a devastating disease that affects millions of people worldwide.
Serotonin (5-hydroxytryptamine, 5-HT) is involved in pain modulation. Several lines of …
Serotonin (5-hydroxytryptamine, 5-HT) is involved in pain modulation. Several lines of …
Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats
SH Avila-Rojas, I Velazquez-Lagunas… - brain research, 2015 - Elsevier
Abstract Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT
receptors. The role of 5-HT 5A receptor in neuropathic pain has not previously studied. The …
receptors. The role of 5-HT 5A receptor in neuropathic pain has not previously studied. The …
Serotonergic modulation of neurovascular transmission: A focus on prejunctional 5-HT receptors/mechanisms
A González-Hernández, BA Marichal-Cancino… - Biomedicines, 2023 - mdpi.com
5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or
neurotransmitter of several nervous system functions. Its actions are complex, and depend …
neurotransmitter of several nervous system functions. Its actions are complex, and depend …
Activation of 5-HT5A receptor in the ventrolateral orbital cortex produces antinociceptive effects in rat models of neuropathic and inflammatory pain
YL Zhao, JL Xu, HY Yi, SS Baba, YX Guo, XM Hou… - …, 2024 - Elsevier
The ventrolateral orbital cortex (VLO) is identified as an integral component of the
endogenous analgesic system comprising a spinal cord-thalamic nucleus submedius-VLO …
endogenous analgesic system comprising a spinal cord-thalamic nucleus submedius-VLO …
Classification and signaling characteristics of 5-HT receptors: toward the concept of 5-HT receptosomes
Abstract Serotonin (5-hydroxytryptamine, 5-HT) is one of the extracellular messengers
capable of activating the largest number of receptors (17 receptors belonging to seven …
capable of activating the largest number of receptors (17 receptors belonging to seven …
The effects of a 5-HT5A receptor antagonist in a ketamine-based rat model of cognitive dysfunction and the negative symptoms of schizophrenia
A Nikiforuk, M Hołuj, T Kos, P Popik - Neuropharmacology, 2016 - Elsevier
Abstract Serotonin (5-HT) receptors still represent promising targets for the development of
novel multireceptor or stand-alone antipsychotic drugs with a potential to ameliorate …
novel multireceptor or stand-alone antipsychotic drugs with a potential to ameliorate …