Redox signaling at the crossroads of human health and disease
Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …
processes with biological activities. Redox homeostasis is a prerequisite for human health …
The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts
The nuclear factor κB (NF-κB) system is critical for various biological functions in numerous
cell types, including the inflammatory response, cell proliferation, survival, differentiation …
cell types, including the inflammatory response, cell proliferation, survival, differentiation …
ZFTA–RELA dictates oncogenic transcriptional programs to drive aggressive supratentorial ependymoma
A Arabzade, Y Zhao, S Varadharajan, HC Chen… - Cancer discovery, 2021 - AACR
More than 60% of supratentorial ependymomas harbor a ZFTA–RELA (ZRfus) gene fusion
(formerly C11orf95–RELA). To study the biology of ZRfus, we developed an autochthonous …
(formerly C11orf95–RELA). To study the biology of ZRfus, we developed an autochthonous …
[HTML][HTML] High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia
Although the BH3-mimetic venetoclax is highly cytotoxic for chronic lymphocytic leukemia
(CLL) cells, some patients with CLL fail to clear minimal residual disease (MRD). We …
(CLL) cells, some patients with CLL fail to clear minimal residual disease (MRD). We …
Sleep fragmentation engages stress-responsive circuitry, enhances inflammation and compromises hippocampal function following traumatic brain injury
ZM Tapp, S Cornelius, A Oberster, JE Kumar… - Experimental …, 2022 - Elsevier
Traumatic brain injury (TBI) impairs the ability to restore homeostasis in response to stress,
indicating hypothalamic-pituitary-adrenal (HPA)-axis dysfunction. Many stressors result in …
indicating hypothalamic-pituitary-adrenal (HPA)-axis dysfunction. Many stressors result in …
[HTML][HTML] Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era
Glucocorticoids are potent anti-inflammatory drugs that are used to treat an extraordinary
range of human disease, including COVID-19, underscoring the ongoing importance of …
range of human disease, including COVID-19, underscoring the ongoing importance of …
[HTML][HTML] Processing stimulus dynamics by the NF-κB network in single cells
Cells at the site of an infection experience numerous biochemical signals that vary in
amplitude, space, and time. Despite the diversity of dynamic signals produced by pathogens …
amplitude, space, and time. Despite the diversity of dynamic signals produced by pathogens …
[HTML][HTML] NFκB signaling in T cell memory
MA Daniels, D Luera, E Teixeiro - Frontiers in Immunology, 2023 - frontiersin.org
Memory T cells play an essential role in protecting against infectious diseases and cancer
and contribute to autoimmunity and transplant rejection. Understanding how they are …
and contribute to autoimmunity and transplant rejection. Understanding how they are …
Role of the NF-κB system in context-specific tuning of the inflammatory gene response
Highlights•Inflammatory genes are activated in a stimulus-type-specific and cell-type-specific
manner.•Deregulated inflammatory gene expressions have been linked to human …
manner.•Deregulated inflammatory gene expressions have been linked to human …
Immunomodulatory effect of glabridin in ovalbumin induced allergic asthma and its comparison with methylprednisolone in a preclinical rodent model
H Muhammad, Z Salahuddin, T Akhtar… - Journal of Cellular …, 2023 - Wiley Online Library
Glabridin, a polyphenolic flavonoid derived from Glycyrrhiza glabra (licorice) roots, has
shown anti‐inflammatory and antioxidant properties. The current study sought to investigate …
shown anti‐inflammatory and antioxidant properties. The current study sought to investigate …