The three-dimensional organisation of the genome modulates biological processes and is,
in turn, transformed by the activity in the nucleus. Not surprisingly, understanding how the …

Abstract This editorial for Volume 16, Issue 3 of Biophysical Reviews highlights the three-
dimensional structural and dynamic information encoded in DNA sequences and introduces …

The linear sequence of DNA provides invaluable information about genes and their
regulatory elements along chromosomes. However, to fully understand gene function and …

The sequence-dependent statistical mechanics of double-stranded nucleic acid, or dsNA, is
believed to be essential in its biological functions. In turn, the equilibrium statistical …

Sequence-dependent properties of the DNA duplex have been accurately described using
extensive molecular dynamics simulations. The RNA duplex meanwhile─ which is typically …

Despite the negative charge of the DNA backbone, acidic residues (Asp/Glu) commonly
participate in the base readout, with a strong preference for cytosine. In fact, in the solved …

Abstract We present BioExcel Building Blocks Workflows, a web-based graphical user
interface (GUI) offering access to a collection of transversal pre-configured biomolecular …

We present CGeNArate, a new model for molecular dynamics simulations of very long
segments of B-DNA in the context of biotechnological or chromatin studies. The developed …

Sequence-specific recognition of transcription factor (TF) binding motifs in the target site of
DNA over the vast amount of non-target DNA is of primary importance for the transcriptional …

Periodic sequences in phase with DNA helical shape are prevalent in genomes due to their
capacity to modulate DNA elasticity on a global scale. However, how this occurs is not well …