Genome interpretation using in silico predictors of variant impact
Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …
personalized therapeutic opportunities. Clinical associations and laboratory experiments …
Cytochrome P450: genotype to phenotype
RH Waring - Xenobiotica, 2020 - Taylor & Francis
The cytochromes P450 comprise a family of enzymes that are responsible for around three-
quarters of all drug metabolism reactions that occur in human populations. Many isoforms of …
quarters of all drug metabolism reactions that occur in human populations. Many isoforms of …
[HTML][HTML] Pharmacogenomics of GPCR drug targets
Natural genetic variation in the human genome is a cause of individual differences in
responses to medications and is an underappreciated burden on public health. Although …
responses to medications and is an underappreciated burden on public health. Although …
An optimized prediction framework to assess the functional impact of pharmacogenetic variants
Y Zhou, S Mkrtchian, M Kumondai… - The …, 2019 - nature.com
Prediction of phenotypic consequences of mutations constitutes an important aspect of
precision medicine. Current computational tools mostly rely on evolutionary conservation …
precision medicine. Current computational tools mostly rely on evolutionary conservation …
Prediction and interpretation of deleterious coding variants in terms of protein structural stability
The classification of human genetic variants into deleterious and neutral is a challenging
issue, whose complexity is rooted in the large variety of biophysical mechanisms that can be …
issue, whose complexity is rooted in the large variety of biophysical mechanisms that can be …
Computational methods for the pharmacogenetic interpretation of next generation sequencing data
Y Zhou, K Fujikura, S Mkrtchian… - Frontiers in …, 2018 - frontiersin.org
Up to half of all patients do not respond to pharmacological treatment as intended. A
substantial fraction of these inter-individual differences is due to heritable factors and a …
substantial fraction of these inter-individual differences is due to heritable factors and a …
Computational assessment of the pharmacological profiles of degradation products of chitosan
Chitosan is a natural polymer revealing an increased potential to be used in different
biomedical applications, including drug delivery systems, and tissue engineering. It implies …
biomedical applications, including drug delivery systems, and tissue engineering. It implies …
A review study: computational techniques for expecting the impact of non-synonymous single nucleotide variants in human diseases
Abstract Non-Synonymous Single-Nucleotide Variants (nsSNVs) and mutations can create a
diversity effect on proteins as changing genotype and phenotype, which interrupts its …
diversity effect on proteins as changing genotype and phenotype, which interrupts its …
Technologies and computational analysis strategies for CRISPR applications
The CRISPR-Cas system offers a programmable platform for eukaryotic genome and
epigenome editing. The ability to perform targeted genetic and epigenetic perturbations …
epigenome editing. The ability to perform targeted genetic and epigenetic perturbations …
[HTML][HTML] Evaluation of computational techniques for predicting non-synonymous single nucleotide variants pathogenicity
The human genetic diseases associated with many factors, one of these factors is the non-
synonymous Single Nucleotide Variants (nsSNVs) cause single amino acid change with …
synonymous Single Nucleotide Variants (nsSNVs) cause single amino acid change with …