The liver has a central role in regulating inflammation by its capacity to secrete a number of
proteins that control both local and systemic inflammatory responses. Chronic inflammation …

Pentoxifylline is a methylxanthine derivative that has been used for several decades in the
symptomatic management of intermittent claudication. For reasons that remain fairly …

Background. Mucosal leishmaniasis is associated with intense tissue damage and high
tumor necrosis factor–α production. Therapeutic failure occurs in up to 42% of cases; …

Abstract Introduction Irinotecan (CPT-11) is an inhibitor of DNA topoisomerase I and is
clinically effective against several cancers. A major toxic effect of CPT-11 is delayed …

Fibrosis is a potentially debilitating disease with high morbidity rates. It is estimated that half
of all deaths that occur in the USA are attributed to fibrotic disorders. Fibrotic disorders are …

Background: There is evidence for an association between major depressive disorder
(MDD) and both inflammatory and phosphodiesterase (PDE) pathways. This study aimed to …

In chronic hepatitis B virus (HBV) infection, inflammation-associated cytokines including
proinflammatory cytokines are involved in the development and progression of liver fibrosis …

Pentoxifylline is a tumor necrosis factor-α (TNF-α) inhibitor that also attenuates the immune
response and decreases tissue inflammation. The association of pentoxifylline with …

We have observed that, after myocardial infarction (MI), rats display apoptosis in the limbic
system that can be prevented by pentoxifylline (PTX), a proinflammatory cytokine inhibitor …

Liver fibrosis results from chronic damage to the liver in conjunction with the progressive
accumulation of fibrillar extracellular matrix proteins. Fibrosis progression in patients with …