Human RecQ helicases in DNA repair, recombination, and replication
DL Croteau, V Popuri, PL Opresko… - Annual review of …, 2014 - annualreviews.org
RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …
The structural biology of CRISPR-Cas systems
Highlights•High-resolution Cascade structures provide a detailed view of Type IE
surveillance complex.•A working model is proposed to better understand Cascade-mediated …
surveillance complex.•A working model is proposed to better understand Cascade-mediated …
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
Topoisomerase I (TOP1) inhibitors are an important class of anticancer drugs. The
cytotoxicity of TOP1 inhibitors can be modulated by replication fork reversal through a …
cytotoxicity of TOP1 inhibitors can be modulated by replication fork reversal through a …
RecQ helicases: conserved guardians of genomic integrity
NB Larsen, ID Hickson - DNA helicases and DNA motor proteins, 2013 - Springer
The RecQ family of DNA helicases is highly conserved throughout evolution, and is
important for the maintenance of genome stability. In humans, five RecQ family members …
important for the maintenance of genome stability. In humans, five RecQ family members …
[HTML][HTML] Superfamily 2 helicases
Superfamily 2 helicases are involved in all aspects of RNA metabolism, and many steps in
DNA metabolism. This review focuses on the basic mechanistic, structural and biological …
DNA metabolism. This review focuses on the basic mechanistic, structural and biological …
Mutations in RECQL Gene Are Associated with Predisposition to Breast Cancer
The genetic cause for approximately 80% of familial breast cancer patients is unknown.
Here, by sequencing the entire exomes of nine early-onset familial breast cancer patients …
Here, by sequencing the entire exomes of nine early-onset familial breast cancer patients …
New insights into DNA helicases as druggable targets for cancer therapy
A Datta, RM Brosh Jr - Frontiers in molecular biosciences, 2018 - frontiersin.org
Small molecules that deter the functions of DNA damage response machinery are
postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing …
postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing …
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes
JA Newman, P Savitsky, CK Allerston… - Nucleic acids …, 2015 - academic.oup.com
Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which
play key roles in the maintenance of genome integrity in all organism groups. We describe …
play key roles in the maintenance of genome integrity in all organism groups. We describe …
Unwinding and rewinding: double faces of helicase?
Y Wu - Journal of nucleic acids, 2012 - Wiley Online Library
Helicases are enzymes that use ATP‐driven motor force to unwind double‐stranded DNA or
RNA. Recently, increasing evidence demonstrates that some helicases also possess …
RNA. Recently, increasing evidence demonstrates that some helicases also possess …
From keys to bulldozers: expanding roles for winged helix domains in nucleic-acid-binding proteins
The winged helix domain (WHD) is a widespread nucleic-acid-binding protein structural
element found in all kingdoms of life. Although the overall structure of the WHD is conserved …
element found in all kingdoms of life. Although the overall structure of the WHD is conserved …