MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …

Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …

Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …

As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well
known for their role in reading the codons on messenger RNAs and translating them into …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Transfer-RNA-derived small RNAs (tsRNAs; also called tRNA-derived fragments) are an
abundant class of small non-coding RNAs whose biological roles are not well understood …

The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …

Pseudouridylation (Ψ) is the most abundant and widespread type of RNA epigenetic
modification in living organisms; however, the biological role of Ψ remains poorly …