Natural and targeted circuit reorganization after spinal cord injury
A spinal cord injury disrupts communication between the brain and the circuits in the spinal
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
cord that regulate neurological functions. The consequences are permanent paralysis, loss …
Transplanting neural progenitor cells to restore connectivity after spinal cord injury
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …
individuals and society. The goal of research in this field is to find a means of restoring lost …
Advances in biomaterial‐based spinal cord injury repair
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …
challenge in neurological clinical practice. Understanding the pathophysiological changes …
Spinal interneurons as gatekeepers to neuroplasticity after injury or disease
LV Zholudeva, VE Abraira… - Journal of …, 2021 - Soc Neuroscience
Spinal interneurons are important facilitators and modulators of motor, sensory, and
autonomic functions in the intact CNS. This heterogeneous population of neurons is now …
autonomic functions in the intact CNS. This heterogeneous population of neurons is now …
How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …
scientific and medical advances, clinically effective regenerative therapies including stem …
Rapid and robust restoration of breathing long after spinal cord injury
PM Warren, SC Steiger, TE Dick… - Nature …, 2018 - nature.com
There exists an abundance of barriers that hinder functional recovery following spinal cord
injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 …
injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 …
Clinical trials targeting secondary damage after traumatic spinal cord injury
ZZ Khaing, JY Chen, G Safarians, S Ezubeik… - International journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) often causes loss of sensory and motor function resulting in a
significant reduction in quality of life for patients. Currently, no therapies are available that …
significant reduction in quality of life for patients. Currently, no therapies are available that …
Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances
SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …
sensory, motor and autonomic impairments after SCI are substantially attributed to …
Effects of biological sex mismatch on neural progenitor cell transplantation for spinal cord injury in mice
Despite advancement of neural progenitor cell transplantation to spinal cord injury clinical
trials, there remains a lack of understanding of how biological sex of transplanted cells …
trials, there remains a lack of understanding of how biological sex of transplanted cells …
The neuroplastic and therapeutic potential of spinal interneurons in the injured spinal cord
The central nervous system is not a static, hard-wired organ. Examples of neuroplasticity,
whether at the level of the synapse, the cell, or within and between circuits, can be found …
whether at the level of the synapse, the cell, or within and between circuits, can be found …