A comprehensive description of how neurons and entire brain regions are interconnected is
fundamental for a mechanistic understanding of brain function and dysfunction …

Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish …

Connections between neurons can be mapped by acquiring and analysing electron
microscopic brain images. In recent years, this approach has been applied to chunks of …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

To fully understand how the human brain works, knowledge of its structure at high resolution
is needed. Presented here is a computationally intensive reconstruction of the ultrastructure …

Abstract Three-dimensional (3D) reconstruction of living brain tissue down to an individual
synapse level would create opportunities for decoding the dynamics and structure–function …

Variation in cytoarchitecture is the basis for the histological definition of cortical areas. We
used single cell transcriptomics and performed cellular characterization of the human cortex …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Animal models play a pivotal role in translational neuroscience but recurrent problems in
data collection, analyses, and interpretation, lack of biomarkers, and a tendency to over …

The molecular mechanisms and evolutionary changes accompanying synapse development
are still poorly understood,. Here we generate a cross-species proteomic map of synapse …