The emergence of widespread multidrug resistance (MDR) is a serious challenge for
therapeutics, food-preservation and crop protection. Frequently, MDR is a result of the action …

Genome-scale metabolic network model (GEM) is a fundamental framework in systems
metabolic engineering. GEM is built upon extensive experimental data and literature …

Since the first large-scale reconstruction of the Saccharomyces cerevisiae metabolic
network 15years ago the development of yeast metabolic models has progressed rapidly …

Multidrug/Multixenobiotic resistance (MDR/MXR) is a widespread phenomenon with clinical,
agricultural and biotechnological implications, where MDR/MXR transporters that are …

Genome-scale stoichiometric models, constrained to optimise biomass production are often
used to predict mutant phenotypes. However, for Saccharomyces cerevisiae, the …

Background Yeast is considered to be a workhorse of the biotechnology industry for the
production of many value-added chemicals, alcoholic beverages and biofuels. Optimization …

Synthetic biology and metabolic engineering enable generation of novel cell factories that
efficiently convert renewable feedstocks into biofuels, bulk, and fine chemicals, thus creating …

Toxic concentrations of monocarboxylic weak acids present in lignocellulosic hydrolyzates
affect cell integrity and fermentative performance of Saccharomyces cerevisiae. In this work …

Thirty years of study of the HAP complex have provided a pretty good picture of the complex
components and put forward its original features. The HAP complex is a modular …

Metabolic flux analysis is a vital tool used to determine the ultimate output of cellular
metabolism and thus detect biotechnologically relevant bottlenecks in productivity. 13C …