Temporal lobe epilepsy semiology
RDG Blair - Epilepsy research and treatment, 2012 - Wiley Online Library
Epilepsy represents a multifaceted group of disorders divided into two broad categories,
partial and generalized, based on the seizure onset zone. The identification of the …
partial and generalized, based on the seizure onset zone. The identification of the …
Epilepsy as a neurodevelopmental disorder
Y Bozzi, S Casarosa, M Caleo - Frontiers in psychiatry, 2012 - frontiersin.org
Epilepsy is characterized by spontaneous recurrent seizures and comprises a diverse group
of syndromes with different etiologies. Epileptogenesis refers to the process whereby the …
of syndromes with different etiologies. Epileptogenesis refers to the process whereby the …
Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
A Yamagata, Y Miyazaki, N Yokoi… - Nature …, 2018 - nature.com
Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand–receptor
complex, LGI1–ADAM22, regulates synaptic transmission and has emerged as a …
complex, LGI1–ADAM22, regulates synaptic transmission and has emerged as a …
Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications
Rationale Autoantibodies to central nervous system (CNS) neuronal surface antigens have
been described in association with autoimmune encephalopathies which prominently …
been described in association with autoimmune encephalopathies which prominently …
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy
N Yokoi, Y Fukata, D Kase, T Miyazaki, M Jaegle… - Nature Medicine, 2015 - nature.com
Epilepsy is one of the most common and intractable brain disorders. Mutations in the human
gene LGI1, encoding a neuronal secreted protein, cause autosomal dominant lateral …
gene LGI1, encoding a neuronal secreted protein, cause autosomal dominant lateral …
LGI proteins in the nervous system
L Kegel, E Aunin, D Meijer, JR Bermingham Jr - ASN neuro, 2013 - journals.sagepub.com
The development and function of the vertebrate nervous system depend on specific
interactions between different cell types. Two examples of such interactions are synaptic …
interactions between different cell types. Two examples of such interactions are synaptic …
Insights into the mechanisms of epilepsy from structural biology of LGI1–ADAM22
A Yamagata, S Fukai - Cellular and Molecular Life Sciences, 2020 - Springer
Epilepsy is one of the most common brain disorders, which can be caused by abnormal
synaptic transmissions. Many epilepsy-related mutations have been identified in synaptic …
synaptic transmissions. Many epilepsy-related mutations have been identified in synaptic …
Mutations in MICAL‐1cause autosomal‐dominant lateral temporal epilepsy
E Dazzo, K Rehberg, R Michelucci… - Annals of …, 2018 - Wiley Online Library
Objective Autosomal‐dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy
characterized by auditory symptoms. Two genes, LGI1 and RELN, encoding secreted …
characterized by auditory symptoms. Two genes, LGI1 and RELN, encoding secreted …
The LGI1 protein: molecular structure, physiological functions and disruption-related seizures
Abstract Leucine-rich, glioma inactivated 1 (LGI1) is a secreted glycoprotein, mainly
expressed in the brain, and involved in central nervous system development and …
expressed in the brain, and involved in central nervous system development and …
Glutamatergic neuron-targeted loss of LGI1 epilepsy gene results in seizures
Abstract Leucin-rich, glioma inactivated 1 (LGI1) is a secreted protein linked to human
seizures of both genetic and autoimmune aetiology. Mutations in the LGI1 gene are …
seizures of both genetic and autoimmune aetiology. Mutations in the LGI1 gene are …