The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium‐derived …

Endothelium‐dependent contractions contribute to endothelial dysfunction in various animal
models of aging, diabetes and cardiovascular diseases. In the spontaneously hypertensive …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Background Short‐term exposures to fine (< 2.5 μm aerodynamic diameter) ambient
particulate‐matter (PM) have been related with increased blood pressure (BP) in controlled …

Aims Immune system activation is a common feature of hypertension pathogenesis.
However, the mechanisms that initiate this activation are not well understood. Innate …

Activation of TLRs (Toll-like receptors) induces gene expression of proteins involved in the
immune system response. TLR4 has been implicated in the development and progression of …

In the spontaneously hypertensive rat (SHR) and aging Wistar–Kyoto rats (WKY),
acetylcholine releases an endothelium‐derived contracting factor (EDCF) produced by …

Aims: This study evaluates a possible relationship between reactive oxygen species (ROS)
and cyclooxygenase (COX)-2-derived products in conductance and resistance arteries from …

Endothelial cells can induce contractions of the underlying vascular smooth muscle by
generating vasoconstrictor prostanoids (endothelium‐dependent contracting factor; EDCF) …

In the aorta of spontaneously hypertensive rats (SHR), the endothelial dysfunction is due to
the release of endothelium‐derived contracting factors (EDCFs) that counteract the …