Advances in germline predisposition to acute leukaemias and myeloid neoplasms
JM Klco, CG Mullighan - Nature Reviews Cancer, 2021 - nature.com
Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …
development of acute leukaemias and other haematopoietic diseases, it has become …
Natural killer cell-mediated immunosurveillance of human cancer
KJ Malmberg, M Carlsten, A Björklund, E Sohlberg… - Seminars in …, 2017 - Elsevier
The contribution of natural killer (NK) cells to immunosurveillance of human cancer remains
debatable. Here, we discuss advances in several areas of human NK cell research, many of …
debatable. Here, we discuss advances in several areas of human NK cell research, many of …
Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes
Abstract Germline SAMD9 and SAMD9L mutations (SAMD9/9L mut) predispose to
myelodysplastic syndromes (MDS) with propensity for somatic rescue. In this study, we …
myelodysplastic syndromes (MDS) with propensity for somatic rescue. In this study, we …
Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity
Chimeric antigen receptors (CARs) have been used to redirect the specificity of autologous
T cells against leukemia and lymphoma with promising clinical results. Extending this …
T cells against leukemia and lymphoma with promising clinical results. Extending this …
Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages
S Feurstein, AM Trottier, N Estrada-Merly… - Blood, The Journal …, 2022 - ashpublications.org
The frequency of pathogenic/likely pathogenic (P/LP) germ line variants in patients with
myelodysplastic syndrome (MDS) diagnosed at age 40 years or less is 15% to 20 …
myelodysplastic syndrome (MDS) diagnosed at age 40 years or less is 15% to 20 …
A landscape of germ line mutations in a cohort of inherited bone marrow failure patients
O Bluteau, M Sebert, T Leblanc… - Blood, The Journal …, 2018 - ashpublications.org
Bone marrow (BM) failure (BMF) in children and young adults is often suspected to be
inherited, but in many cases diagnosis remains uncertain. We studied a cohort of 179 …
inherited, but in many cases diagnosis remains uncertain. We studied a cohort of 179 …
Sequencing of human genomes with nanopore technology
Whole-genome sequencing (WGS) is becoming widely used in clinical medicine in
diagnostic contexts and to inform treatment choice. Here we evaluate the potential of the …
diagnostic contexts and to inform treatment choice. Here we evaluate the potential of the …
Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells
M Carlsten, M Järås - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells are large granular lymphocytes involved in our defense against
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …
Monogenic and polygenic inheritance become instruments for clonal selection
Clonally expanded blood cells that contain somatic mutations (clonal haematopoiesis) are
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …
commonly acquired with age and increase the risk of blood cancer,,,,,,,–. The blood clones …
The genomic landscape of pediatric myelodysplastic syndromes
JR Schwartz, J Ma, T Lamprecht, M Walsh… - Nature …, 2017 - nature.com
Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In
contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here …
contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here …