AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level

A Stylianou, M Lekka, T Stylianopoulos - Nanoscale, 2018 - pubs.rsc.org
Cancer development and progression are closely associated with changes both in the
mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix …

Atomic force microscopy on biological materials related to pathological conditions

A Stylianou, SV Kontomaris, C Grant… - Scanning, 2019 - Wiley Online Library
Atomic force microscopy (AFM) is an easy‐to‐use, powerful, high‐resolution microscope that
allows the user to image any surface and under any aqueous condition. AFM has been used …

The Hertz model in AFM nanoindentation experiments: applications in biological samples and biomaterials

SV Kontomaris - Micro and Nanosystems, 2018 - ingentaconnect.com
AFM nanoindentation is a modern technique which is used for the determination of the
mechanical properties of materials and biomaterials. With regards to the nanoindentation …

Decellularized caprine liver extracellular matrix as a 2D substrate coating and 3D hydrogel platform for vascularized liver tissue engineering

T Agarwal, R Narayan, S Maji… - Journal of tissue …, 2018 - Wiley Online Library
Abstract Development of a vascularized liver tissue construct is a need of an hour to
circumvent the current demand of liver transplantation in health care sector. An appropriate …

Atomic Force Microscopy for Collagen‐Based Nanobiomaterials

A Stylianou - Journal of Nanomaterials, 2017 - Wiley Online Library
Novel nanobiomaterials are increasingly gaining ground in bioengineering research.
Among the numerous biomaterials, collagen‐nanobiomaterials, such as collagen thin films …

Atomic force microscopy for university students: applications in biomaterials

SV Kontomaris, A Stylianou - European Journal of Physics, 2017 - iopscience.iop.org
Atomic force microscopy (AFM) is a powerful tool used in the investigation of the structural
and mechanical properties of a wide range of materials including biomaterials. It provides …

Atomic force microscopy probing of cancer cells and tumor microenvironment components

A Stylianou, T Stylianopoulos - BioNanoScience, 2016 - Springer
Cancer cells have different characteristics from normal cells in terms of morphology, cell–cell
interactions, cytoskeleton organization, cell growth rates, and cell-extracellular matrix …

Assessing collagen D-band periodicity with atomic force microscopy

A Stylianou - Materials, 2022 - mdpi.com
The collagen superfamily includes more than fifty collagen and/or collagen-like proteins with
fibril-forming collagen type I being the most abundant protein within the extracellular matrix …

Exploring the nano-surface of collagenous and other fibrotic tissues with AFM

A Stylianou, V Gkretsi, CS Patrickios… - Fibrosis: Methods and …, 2017 - Springer
Atomic force microscope (AFM) is a powerful and invaluable tool for imaging and probing
the mechanical properties of biological samples at the nanometric scale. The importance of …

[HTML][HTML] Accurate Modelling of AFM Force-Indentation Curves with Blunted Indenters at Small Indentation Depths

SV Kontomaris, A Malamou, A Stylianou - Micromachines, 2024 - mdpi.com
When testing biological samples with atomic force microscopy (AFM) nanoindentation using
pyramidal indenters, Sneddon's equation is commonly used for data processing …