DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …

Since the identification of B cells in 1965 (Cooper et al. 1965), three has been tremendous
progress in our understanding of B cell development, maturation and function. A number of …

Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of
ordered gene rearrangements which must be successfully performed if the cell is to survive …

A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen
receptor is the central feature of the adaptive immune system that evolved in our vertebrate …

V (D) J recombination assembles immunoglobulin and T cell receptor genes during
lymphocyte development through a series of carefully orchestrated DNA breakage and …

Innate immunity has been considered only to provide rapid, incomplete antimicrobial host
defense until the slower, more definitive acquired immune response develops. However …

Abstract V (D) J recombination is of fundamental importance to the generation of diverse
antigen receptor repertoires. We review our current understanding of the V (D) J …

▪ Abstract V (D) J recombination is the specialized DNA rearrangement used by cells of the
immune system to assemble immunoglobulin and T-cell receptor genes from the preexisting …

Abstract V (D) J recombination assembles antigen receptor variable region genes from
component germline variable (V), diversity (D), and joining (J) gene segments. For B cells …

The DNA-dependent protein kinase (DNA–PK) is a nuclear serine/threonine protein kinase
that is activated upon association with DNA. Biochemical and genetic data have revealed …