Cisplatin and other platinum-based chemotherapeutic drugs have been used extensively for
the treatment of human cancers such as bladder, blood, breast, cervical, esophageal, head …

Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …

Gynecological cancers are known for being very aggressive at their advanced stages.
Indeed, the survival rate of both ovarian and endometrial cancers is very low when …

Simple Summary The progress of next-generation sequencing technologies has raised
huge expectations for precision-medicine therapy approaches in breast cancer and triple …

Tumor progression is associated with dedifferentiated histopathologies concomitant with
cancer cell survival within a changing, and often hostile, tumor microenvironment. These …

Cisplatin has long been a first-line chemotherapeutic agent in the treatment of cancer,
largely for solid tumors. During the course of the past two decades, autophagy has been …

Objectives The aims of this study were to investigate the functions of GAS5 as a tumor
suppressor in cervical cancer and explore the mechanism. Methods The expression of …

Chemotherapy resistance is a major contributor to poor treatment responses and tumour
relapse, the development of which has been strongly linked to the action of cancer stem …

Background Mutation of TP53 is the most frequent genetic alteration in high-grade serous
ovarian cancer (HGSOC). The impact of hotspot mutations of TP53 and protein levels on …

The serine/threonine kinase AKT, also known as protein kinase B (PKB), is the major
substrate to phosphoinositide 3-kinase (PI3K) and consists of three paralogs: AKT1 (PKBα) …