Cerebral hypoxic vasodilation is poorly understood in humans, which undermines the
development of therapeutics to optimize cerebral oxygen delivery. Across four investigations …

High‐altitude (HA) hypoxia may alter the structural–functional integrity of the neurovascular
unit (NVU). Herein, we compared male lowlanders (n= 9) at sea level (SL) and after 14 days …

High-altitude (> 2,500 m) exposure results in increased muscle sympathetic nervous activity
(MSNA) in acclimatizing lowlanders. However, little is known about how altitude affects …

Key points Humans suffering from polycythaemia undergo multiple circulatory adaptations
including changes in blood rheology and structural and functional vascular adaptations to …

The high-altitude maladaptation syndrome known as chronic mountain sickness (CMS) is
characterized by polycythemia and is associated with proteinuria despite unaltered …

High altitude-related excessive erythrocytosis (EE) is associated with increased
cardiovascular risk. The experimental aim of this study was to determine the effects of …

Chronic exposure to hypoxia (high‐altitude, HA;> 4000 m) attenuates the vasodilatory
response to exercise and is associated with a persistent increase in basal sympathetic nerve …

Brewster, L. Madden, Anthony R. Bain, Vinicius P. Garcia, Noah M. DeSouza, Michael M.
Tymko, Jared J. Greiner, and Philip N. Ainslie. Global REACH 2018: high altitude-related …

High-altitude exposure results in a hyperventilatory-induced respiratory alkalosis followed
by renal compensation (bicarbonaturia) to return arterial blood pH (pHa) toward sea-level …

High altitude‐induced hypoxaemia is often associated with peripheral vascular dysfunction.
However, the basic mechanism (s) underlying high‐altitude vascular impairments remains …