The hallmarks of myotonic dystrophy type 1 muscle dysfunction
LL Ozimski, M Sabater‐Arcis, A Bargiela… - Biological …, 2021 - Wiley Online Library
ABSTRACT Myotonic dystrophy type 1 (DM1) is the most prevalent form of muscular
dystrophy in adults and yet there are currently no treatment options. Although this disease …
dystrophy in adults and yet there are currently no treatment options. Although this disease …
[HTML][HTML] Myotonic dystrophy: emerging mechanisms for DM1 and DM2
DH Cho, SJ Tapscott - Biochimica et Biophysica Acta (BBA)-Molecular …, 2007 - Elsevier
Myotonic dystrophy (DM) is a complex multisystemic disorder linked to two different genetic
loci. Myotonic dystrophy type 1 (DM1) is caused by an expansion of a CTG repeat located in …
loci. Myotonic dystrophy type 1 (DM1) is caused by an expansion of a CTG repeat located in …
Long noncoding RNAs and RNA‐binding proteins in oxidative stress, cellular senescence, and age‐related diseases
C Kim, D Kang, EK Lee, JS Lee - Oxidative Medicine and …, 2017 - Wiley Online Library
Cellular senescence is a complex biological process that leads to irreversible cell‐cycle
arrest. Various extrinsic and intrinsic insults are associated with the onset of cellular …
arrest. Various extrinsic and intrinsic insults are associated with the onset of cellular …
Expanded CTG repeats within the DMPK 3′ UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy
JP Orengo, P Chambon, D Metzger… - Proceedings of the …, 2008 - National Acad Sciences
Severe skeletal muscle wasting is the most debilitating symptom experienced by individuals
with myotonic dystrophy type 1 (DM1). We present a DM1 mouse model with inducible and …
with myotonic dystrophy type 1 (DM1). We present a DM1 mouse model with inducible and …
Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation
The steroid receptor RNA activator (SRA) has the unusual property to function as both a non-
coding RNA (ncRNA) and a protein SRAP. SRA ncRNA is known to increase the activity of a …
coding RNA (ncRNA) and a protein SRAP. SRA ncRNA is known to increase the activity of a …
RNA pathogenesis of the myotonic dystrophies
JW Day, LPW Ranum - Neuromuscular disorders, 2005 - Elsevier
Myotonic dystrophy (dystrophia myotonica, DM) is the most common form of muscular
dystrophy in adults. The presence of two genetic forms of this complex multisystemic disease …
dystrophy in adults. The presence of two genetic forms of this complex multisystemic disease …
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1
Myotonic dystrophy type I (DM1) is a multisystemic autosomal-dominant inherited human
disorder that is caused by CTG microsatellite repeat expansions (MREs) in the 3 …
disorder that is caused by CTG microsatellite repeat expansions (MREs) in the 3 …
GSK3β mediates muscle pathology in myotonic dystrophy
K Jones, C Wei, P Iakova, E Bugiardini… - The Journal of …, 2012 - Am Soc Clin Investig
Myotonic dystrophy type 1 (DM1) is a complex neuromuscular disease characterized by
skeletal muscle wasting, weakness, and myotonia. DM1 is caused by the accumulation of …
skeletal muscle wasting, weakness, and myotonia. DM1 is caused by the accumulation of …
Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients
Background MicroRNAs are highly conserved, noncoding RNAs involved in post-
transcriptional gene silencing. They have been shown to participate in a wide range of …
transcriptional gene silencing. They have been shown to participate in a wide range of …
Circular RNAs in myogenesis
Skeletal muscles have an immense ability to regenerate from the muscle stem cells called
satellite cells. The process of skeletal muscle regeneration is called myogenesis, which …
satellite cells. The process of skeletal muscle regeneration is called myogenesis, which …