Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction
pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these …

There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors constitute
the largest family of eukaryotic signal transduction proteins that communicate across the …

Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness.
Sex differences in dopaminergic signaling have been acknowledged for decades and have …

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between
distinct sites), used initially to explain feedback-inhibited enzymes, was presented by …

Abstract Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Over the 75‐year lifetime of the British Pharmacological Society there has been an
enormous expansion in our understanding of how opioid drugs act on the nervous system …

G protein‐coupled receptor (GPCR) agonists, including neurotransmitters, hormones,
chemokines, and bioactive lipids, act as potent cellular growth factors and have been …

Chemical biology approaches have a long history in the exploration of the G‐protein‐
coupled receptor (GPCR) family, which represents the largest and most important group of …