Computer-aided drug design (CADD) is one of the pivotal approaches to contemporary pre-
clinical drug discovery, and various computational techniques and software programs are …

Analysis of the literature involving computational modeling of diseases and drug design with
the aid of experimental spectroscopic techniques reveals that this specific combination of …

Toll-like receptor 4 (TLR4), along with its accessory protein myeloid differentiation factor 2
(MD-2), builds a heterodimeric complex that specifically recognizes lipopolysaccharides …

The nitrile containing Ru (II) polypyridyl complex [Ru (phen) 2 (11, 12-dCN-dppz)] 2+(1) is
shown to act as a sensitive infrared probe of G-quadruplex (G4) structures. UV–visible …

Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules.
While the interaction of paclitaxel with microtubules is well described, the lack of high …

In this study, we extracted nisin from Lactococcus lactis, purified it, and examined it for
biological properties such as antibacterial and anticancer activities. The purified nisin was …

Microtubule-targeting agents that bind at the colchicine-site of tubulin are of particular
interest in antitumoral therapy due to their dual mechanism of action as antimitotics and …

Lung infection by Burkholderia species, in particular Burkholderia cenocepacia, accelerates
tissue damage and increases post-lung transplant mortality in cystic fibrosis patients. Host …

YAP is a WW domain-containing effector of the Hippo tumor suppressor pathway, and the
object of heightened interest as a potent oncogene and stemness factor. YAP has two major …

Bacterial cell-wall hydrolases must be tightly regulated during bacterial cell division to
prevent aberrant cell lysis and to allow final separation of viable daughter cells. In a …