Signaling pathways in obesity: mechanisms and therapeutic interventions
X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …
excessive fat accumulation in the body, obesity sharply increases the risk of several …
Pleiotropic effects of GLP-1 and analogs on cell signaling, metabolism, and function
J Rowlands, J Heng, P Newsholme… - Frontiers in …, 2018 - frontiersin.org
The incretin hormone Glucagon-Like Peptide-1 (GLP-1) is best known for its “incretin effect”
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …
in restoring glucose homeostasis in diabetics, however, it is now apparent that it has a …
[HTML][HTML] GLP-1 and GIP receptor signaling in beta cells–a review of receptor interactions and co-stimulation
A Mayendraraj, MM Rosenkilde, LS Gasbjerg - Peptides, 2022 - Elsevier
Glucagon-like peptide 1 receptor (GLP-1R) and glucose-dependent insulinotropic
polypeptide receptor (GIPR) are two class B1 G protein-coupled receptors, which are …
polypeptide receptor (GIPR) are two class B1 G protein-coupled receptors, which are …
Food protein-derived bioactive peptides in management of type 2 diabetes
P Patil, S Mandal, SK Tomar, S Anand - European journal of nutrition, 2015 - Springer
Abstract Background Type 2 diabetes (T2D), one of the major common human health
problems, is growing at an alarming rate around the globe. Alpha-glucosidase and …
problems, is growing at an alarming rate around the globe. Alpha-glucosidase and …
Regulation of glucose homeostasis by GLP-1
P Nadkarni, OG Chepurny, GG Holz - Progress in molecular biology and …, 2014 - Elsevier
Abstract Glucagon-like peptide-1 (7–36) amide (GLP-1) is a secreted peptide that acts as a
key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric …
key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric …
Biochemical and metabolic mechanisms by which dietary whey protein may combat obesity and Type 2 diabetes
D Jakubowicz, O Froy - The Journal of nutritional biochemistry, 2013 - Elsevier
Consumption of milk and dairy products has been associated with reduced risk of metabolic
disorders and cardiovascular disease. Milk contains two primary sources of protein, casein …
disorders and cardiovascular disease. Milk contains two primary sources of protein, casein …
Diabetes and beta cell function: from mechanisms to evaluation and clinical implications
S Cernea, M Dobreanu - Biochemia medica, 2013 - hrcak.srce.hr
Sažetak Diabetes is a complex, heterogeneous condition that has beta cell dysfunction at its
core. Many factors (eg hyperglycemia/glucotoxicity, lipotoxicity, autoimmunity, inflammation …
core. Many factors (eg hyperglycemia/glucotoxicity, lipotoxicity, autoimmunity, inflammation …
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes
The intrahepatic milieu is inhospitable to intraportal islet allografts,–, limiting their
applicability for the treatment of type 1 diabetes. Although the subcutaneous space …
applicability for the treatment of type 1 diabetes. Although the subcutaneous space …
First-phase insulin secretion: can its evaluation direct therapeutic approaches?
G Di Giuseppe, G Ciccarelli, L Soldovieri… - Trends in Endocrinology …, 2023 - cell.com
Our work is aimed at unraveling the role of the first-phase insulin secretion in the natural
history of type 2 diabetes mellitus (T2DM) and its interrelationship with insulin resistance …
history of type 2 diabetes mellitus (T2DM) and its interrelationship with insulin resistance …
Multifaceted roles of GLP-1 and its analogs: a review on molecular mechanisms with a cardiotherapeutic perspective
Diabetes is one of the chronic metabolic disorders which poses a multitude of life-
debilitating challenges, including cardiac muscle impairment, which eventually results in …
debilitating challenges, including cardiac muscle impairment, which eventually results in …