Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications
Drug development has been a principal driving force in the rapid maturation of the field of
medicinal chemistry during the past several decades. During this period, the intriguing and …
medicinal chemistry during the past several decades. During this period, the intriguing and …
Heterocyclic scaffolds: centrality in anticancer drug development
I Ali, M Nadeem Lone, ZA Al-Othman… - Current drug …, 2015 - ingentaconnect.com
Cancer has been cursed for human beings for long time. Millions people lost their lives due
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …
to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; …
An insight into the therapeutic potential of quinazoline derivatives as anticancer agents
I Ahmad - MedChemComm, 2017 - pubs.rsc.org
Cancer is one of the major causes of worldwide human mortality. A wide range of cytotoxic
drugs are available on the market, and several compounds are in different phases of clinical …
drugs are available on the market, and several compounds are in different phases of clinical …
Medicinal perspective of quinazolinone derivatives: Recent developments and structure–activity relationship studies
Heterocyclic rings have long piqued the interest of medicinal chemists. Quinazolinone is a
fused nitrogen‐based heterocyclic moiety. Some of quinazolinone derivatives have …
fused nitrogen‐based heterocyclic moiety. Some of quinazolinone derivatives have …
Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions
A Saleh, HM ElFayoumi, M Youns… - … Schmiedeberg's archives of …, 2019 - Springer
Cancer is a broad term used to describe a large number of diseases characterized by
uncontrolled cell proliferation that leads to tumor production. Cancer is associated with …
uncontrolled cell proliferation that leads to tumor production. Cancer is associated with …
The natural flavonoid fisetin inhibits cellular proliferation of hepatic, colorectal, and pancreatic cancer cells through modulation of multiple signaling pathways
M Youns, W Abdel Halim Hegazy - PLoS One, 2017 - journals.plos.org
Digestive cancers are major causes of mortality and morbidity worldwide. Fisetin, a naturally
occurring flavonoid, has been previously shown anti-proliferative, anti-cancer …
occurring flavonoid, has been previously shown anti-proliferative, anti-cancer …
Synthesis, characterization and apoptotic activity of quinazolinone Schiff base derivatives toward MCF-7 cells via intrinsic and extrinsic apoptosis pathways
The current study investigated the cytotoxic effect of 3-(5-chloro-2-hydroxybenzylideneamino
)-2-(5-chloro-2-hydroxyphenyl)-2, 3-dihydroquinazolin-41 (H)-one (A) and 3-(5-nitro-2 …
)-2-(5-chloro-2-hydroxyphenyl)-2, 3-dihydroquinazolin-41 (H)-one (A) and 3-(5-nitro-2 …
[HTML][HTML] Design, synthesis, antiproliferative activity, and cell cycle analysis of new thiosemicarbazone derivatives targeting ribonucleotide reductase
MF Ahmed, AH Almalki - Arabian Journal of Chemistry, 2021 - Elsevier
Thiosemicarbazones are potential anticancer agents. In this study, we designed and
synthesized new thiosemicarbazone derivatives as anticancer agents. The antiproliferative …
synthesized new thiosemicarbazone derivatives as anticancer agents. The antiproliferative …
New potential antitumor quinazolinones derived from dynamic 2-undecyl benzoxazinone: synthesis and cytotoxic evaluation
MH Hekal, FSM Abu El-Azm - Synthetic Communications, 2018 - Taylor & Francis
Since the quinazoline and its derivatives have been considered as a novel class of cancer
chemotherapeutic agents that show promising activity against different tumors, a new series …
chemotherapeutic agents that show promising activity against different tumors, a new series …
Anticancer activity of salicin and fenofibrate
Cancer refers to a disorder of cell proliferation that leads to tumor production. Cancer is
usually treated by surgery, chemotherapeutic drugs, and radiation. Despite the presence of …
usually treated by surgery, chemotherapeutic drugs, and radiation. Despite the presence of …