Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria
CB Scarim, DH Jornada, MGM Machado… - European journal of …, 2019 - Elsevier
Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting
as primary pharmacophores) in many compounds that are useful to treat several diseases …
as primary pharmacophores) in many compounds that are useful to treat several diseases …
Thiazolidin-4-one-based derivatives–Efficient tools for designing antiprotozoal agents. A review of the last decade
H Tuszewska, J Szczepański, S Mandziuk… - Bioorganic Chemistry, 2023 - Elsevier
Thiazolidin-4-one derivatives have a wide range of therapeutic implementations and clinical
significance for medicinal chemistry. This heterocyclic ring has been reported to possess a …
significance for medicinal chemistry. This heterocyclic ring has been reported to possess a …
Thiazolidinone/thiazole based hybrids–New class of antitrypanosomal agents
A Kryshchyshyn, D Kaminskyy, O Karpenko… - European journal of …, 2019 - Elsevier
Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …
Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity
Abstract A series of novel 2-(5-aminomethylene-4-oxo-2-thioxothiazolidin-3-yl)-3-
phenylpropionic acid ethyl esters has been synthesized. Target compounds were evaluated …
phenylpropionic acid ethyl esters has been synthesized. Target compounds were evaluated …
Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi
GB de Oliveira Filho, MV de Oliveira Cardoso… - European Journal of …, 2017 - Elsevier
Chagas disease is one of the most significant health problems in the American continent.
benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and …
benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and …
1, 3-Thiazole derivatives as privileged structures for anti-Trypanosoma cruzi activity: Rational design, synthesis, in silico and in vitro studies
MCH de Barros Dias, MS Barbalho… - European Journal of …, 2023 - Elsevier
Chagas disease is a deadly and centenary neglected disease that is recently surging as a
potential global threat. Approximately 30% of infected individuals develop chronic Chagas …
potential global threat. Approximately 30% of infected individuals develop chronic Chagas …
New 1, 3-thiazole derivatives and their biological and ultrastructural effects on Trypanosoma cruzi
PAT de Moraes Gomes, M de Oliveira Barbosa… - European Journal of …, 2016 - Elsevier
In previous studies, the compound 3-(bromopropiophenone) thiosemicarbazone was
described as a potent anti-Trypanosoma cruzi and cruzain inhibitor. In view to optimize this …
described as a potent anti-Trypanosoma cruzi and cruzain inhibitor. In view to optimize this …
Synthesis and structure–activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma Cruzi Cruzain
JWP Espíndola, MV de Oliveira Cardoso… - European Journal of …, 2015 - Elsevier
The discovery of new antiparasitic compounds against Trypanosoma cruzi, the etiological
agent of Chagas disease, is necessary. Novel aryloxy/aryl thiosemicarbazone-based …
agent of Chagas disease, is necessary. Novel aryloxy/aryl thiosemicarbazone-based …
The design, synthesis, and in vitro trypanocidal and leishmanicidal activities of 1, 3-thiazole and 4-thiazolidinone ester derivatives
M Haroon, MCH de Barros Dias, AC da Silva Santos… - RSC …, 2021 - pubs.rsc.org
Chagas and leishmaniasis are both neglected tropical diseases, whose inefficient therapies
have made them remain the cause for millions of deaths worldwide. Given this, we …
have made them remain the cause for millions of deaths worldwide. Given this, we …
Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death
DRM Moreira, ADT de Oliveira… - European journal of …, 2014 - Elsevier
Chagas disease, caused by Trypanosoma cruzi, is a life-threatening infection leading to
approximately 12,000 deaths per year. T. cruzi is susceptible to thiosemicarbazones, making …
approximately 12,000 deaths per year. T. cruzi is susceptible to thiosemicarbazones, making …