Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting
as primary pharmacophores) in many compounds that are useful to treat several diseases …

Thiazolidin-4-one derivatives have a wide range of therapeutic implementations and clinical
significance for medicinal chemistry. This heterocyclic ring has been reported to possess a …

Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …

Abstract A series of novel 2-(5-aminomethylene-4-oxo-2-thioxothiazolidin-3-yl)-3-
phenylpropionic acid ethyl esters has been synthesized. Target compounds were evaluated …

Chagas disease is one of the most significant health problems in the American continent.
benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and …

Chagas disease is a deadly and centenary neglected disease that is recently surging as a
potential global threat. Approximately 30% of infected individuals develop chronic Chagas …

In previous studies, the compound 3-(bromopropiophenone) thiosemicarbazone was
described as a potent anti-Trypanosoma cruzi and cruzain inhibitor. In view to optimize this …

The discovery of new antiparasitic compounds against Trypanosoma cruzi, the etiological
agent of Chagas disease, is necessary. Novel aryloxy/aryl thiosemicarbazone-based …

Chagas and leishmaniasis are both neglected tropical diseases, whose inefficient therapies
have made them remain the cause for millions of deaths worldwide. Given this, we …

Chagas disease, caused by Trypanosoma cruzi, is a life-threatening infection leading to
approximately 12,000 deaths per year. T. cruzi is susceptible to thiosemicarbazones, making …