Abstract B-cell lymphoma-2 (Bcl-2) proteins family is an essential checkpoint in apoptosis.
Extensive evidences suggested that overexpression of anti-apoptotic Bcl-2 proteins can be …

Diabetic kidney disease (DKD) is one of the major microvascular complications of diabetes
mellitus, with relatively high morbidity and mortality globally but still in short therapeutic …

Abstract Background Coronavirus disease-2019 (COVID-19) is an infectious pandemic
caused by SARS-CoV-2. SARS-CoV-2 main protease (M pro) and spike protein are crucial …

HCC has remained one of the challenging cancers to treat, owing to the paucity of drugs
targeting the critical survival pathways. Considering the cancer cells are deficient in DNase …

Objective: Diabetic nephropathy (DN) is one of the most severe and frequent diabetic
complications. MicroRNAs (miRNAs) have been reported to play a vital role in DN …

COVID-19 is an infectious pandemic caused by the SARS-CoV-2 virus. The critical
components of SARS-CoV-2 are the spike protein (S-protein) and the main protease (Mpro) …

Salt-inducible kinases (SIKs) are calcium/calmodulin-dependent protein kinase (CAMK)-like
(CAMKL) family members implicated in insulin signal transduction, metabolic regulation …

Abstract Background Circular RNAs (circRNAs) have emerged as vital regulators in human
cancers, including colorectal cancer (CRC). In this study, we aimed to explore the roles of …

Background CircRNA plays an important role in the development of tumors, but its
mechanism of action in ovarian cancer is still unclear. Methods The expression level of …

Objectives While a fine balance in the pro-apoptotic and anti-apoptotic family members of
the B-cell lymphoma-2 (Bcl-2) protein family represents a normal signaling profile, a tilt in …