Single and dual target inhibitors based on Bcl-2: Promising anti-tumor agents for cancer therapy
T Liu, Z Wu, Y He, Y Xiao, C Xia - European Journal of Medicinal Chemistry, 2020 - Elsevier
Abstract B-cell lymphoma-2 (Bcl-2) proteins family is an essential checkpoint in apoptosis.
Extensive evidences suggested that overexpression of anti-apoptotic Bcl-2 proteins can be …
Extensive evidences suggested that overexpression of anti-apoptotic Bcl-2 proteins can be …
Long non-coding RNAs in the pathogenesis of diabetic kidney disease
M Hu, Q Ma, B Liu, Q Wang, T Zhang… - Frontiers in cell and …, 2022 - frontiersin.org
Diabetic kidney disease (DKD) is one of the major microvascular complications of diabetes
mellitus, with relatively high morbidity and mortality globally but still in short therapeutic …
mellitus, with relatively high morbidity and mortality globally but still in short therapeutic …
Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation
Abstract Background Coronavirus disease-2019 (COVID-19) is an infectious pandemic
caused by SARS-CoV-2. SARS-CoV-2 main protease (M pro) and spike protein are crucial …
caused by SARS-CoV-2. SARS-CoV-2 main protease (M pro) and spike protein are crucial …
[HTML][HTML] Deoxyribonuclease 1-like 3 inhibits hepatocellular carcinoma progression by inducing apoptosis and reprogramming glucose metabolism
Y Xiao, K Yang, P Liu, D Ma, P Lei… - International Journal of …, 2022 - ncbi.nlm.nih.gov
HCC has remained one of the challenging cancers to treat, owing to the paucity of drugs
targeting the critical survival pathways. Considering the cancer cells are deficient in DNase …
targeting the critical survival pathways. Considering the cancer cells are deficient in DNase …
MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3
L Wang, H Li - Bioscience Reports, 2020 - portlandpress.com
Objective: Diabetic nephropathy (DN) is one of the most severe and frequent diabetic
complications. MicroRNAs (miRNAs) have been reported to play a vital role in DN …
complications. MicroRNAs (miRNAs) have been reported to play a vital role in DN …
Traditional medicinal plants against replication, maturation and transmission targets of SARS-CoV-2: computational investigation
COVID-19 is an infectious pandemic caused by the SARS-CoV-2 virus. The critical
components of SARS-CoV-2 are the spike protein (S-protein) and the main protease (Mpro) …
components of SARS-CoV-2 are the spike protein (S-protein) and the main protease (Mpro) …
Dasatinib–SIK2 Binding Elucidated by Homology Modeling, Molecular Docking, and Dynamics Simulations
M Shi, L Wang, P Li, J Liu, L Chen, D Xu - ACS omega, 2021 - ACS Publications
Salt-inducible kinases (SIKs) are calcium/calmodulin-dependent protein kinase (CAMK)-like
(CAMKL) family members implicated in insulin signal transduction, metabolic regulation …
(CAMKL) family members implicated in insulin signal transduction, metabolic regulation …
CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR‐485‐5p/SLC38A1 axis
J Yu, X Chen, J Li, F Wang - European Journal of Clinical …, 2021 - Wiley Online Library
Abstract Background Circular RNAs (circRNAs) have emerged as vital regulators in human
cancers, including colorectal cancer (CRC). In this study, we aimed to explore the roles of …
cancers, including colorectal cancer (CRC). In this study, we aimed to explore the roles of …
CircRNA hsa_circ_0013958 may contribute to the development of ovarian cancer by affecting epithelial‐mesenchymal transition and apoptotic signaling pathways
C Pei, H Wang, C Shi, C Zhang… - Journal of clinical …, 2020 - Wiley Online Library
Background CircRNA plays an important role in the development of tumors, but its
mechanism of action in ovarian cancer is still unclear. Methods The expression level of …
mechanism of action in ovarian cancer is still unclear. Methods The expression level of …
[HTML][HTML] Reinstating apoptosis using putative Bcl-xL natural product inhibitors: Molecular docking and ADMETox profiling investigations
ID Boyenle, AT Ogunlana, AQK Oyedele… - Journal of Taibah …, 2023 - Elsevier
Objectives While a fine balance in the pro-apoptotic and anti-apoptotic family members of
the B-cell lymphoma-2 (Bcl-2) protein family represents a normal signaling profile, a tilt in …
the B-cell lymphoma-2 (Bcl-2) protein family represents a normal signaling profile, a tilt in …