Structures of influenza A virus RNA polymerase offer insight into viral genome replication

H Fan, AP Walker, L Carrique, JR Keown… - Nature, 2019 - nature.com
Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from
the transmission of novel zoonotic influenza A viruses to humans,. Influenza A viruses …

[HTML][HTML] Exploring the alternative virulence determinants PB2 S155N and PA S49Y/D347G that promote mammalian adaptation of the H9N2 avian influenza virus in …

Y Guo, X Bai, Z Liu, B Liang, Y Zheng, S Dankar… - Veterinary …, 2023 - Springer
The occurrence of human infections caused by avian H9N2 influenza viruses has raised
concerns regarding the potential for human epidemics and pandemics. The molecular basis …

[HTML][HTML] Engineering an optimal Y280-lineage H9N2 vaccine strain by tuning PB2 activity

SH An, SM Hong, JH Song, SE Son, CY Lee… - International Journal of …, 2023 - mdpi.com
H9N2 avian influenza A viruses (AIVs) cause economic losses in the poultry industry and
provide internal genomic segments for the evolution of H5N1 and H7N9 AIVs into more …

[HTML][HTML] Selection of an optimal recombinant egyptian H9N2 avian influenza vaccine strain for poultry with high antigenicity and safety

SH An, SE Son, JH Song, SM Hong, CY Lee, NH Lee… - Vaccines, 2022 - mdpi.com
For the development of an optimized Egyptian H9N2 vaccine candidate virus for poultry,
various recombinant Egyptian H9N2 viruses generated by a PR8-based reverse genetics …

[HTML][HTML] Influenza A virus RNA polymerase structures provide insights into viral genome replication

H Fan, AP Walker, L Carrique, JR Keown, IS Martin… - Nature, 2019 - ncbi.nlm.nih.gov
Influenza A viruses (IAV) are responsible for seasonal epidemics, and pandemics can arise
from novel zoonotic influenza A viruses transmitting to humans 1, 2. IAV contain a …

[HTML][HTML] Novel mutations evading avian immunity around the receptor binding site of the clade 2.3. 2.1 c hemagglutinin gene reduce viral thermostability and …

SH An, CY Lee, SM Hong, CS Song, JH Kim, HJ Kwon - Viruses, 2019 - mdpi.com
Since 2007, highly pathogenic clade 2.3. 2 H5N1 avian influenza A (A (H5N1)) viruses have
evolved to clade 2.3. 2.1 a, b, and c; currently only 2.3. 2.1 c A (H5N1) viruses circulate in …

Development of highly productive and mammalian non-pathogenic recombinant avian influenza vaccine strains

안세희 - 2020 - s-space.snu.ac.kr
Avian influenza viruses (AIVs) are highly infectious pathogen of waterfowls and can
overcome species barriers to infect mammals by acquiring cumulative mutations. Low …